Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity?

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Abstract

Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial fibrosis and tubular atrophy, which impairs long-term allograft survival. The mineralocorticoid hormone aldosterone induces fibrosis in numerous organs, including the kidney. Evidence from animal models suggests a beneficial effect of aldosterone antagonism in reducing calcineurin inhibitor-induced nephrotoxicity. This review summarizes current evidence of mineralocorticoid receptor antagonism in animal models of calcineurin inhibitor-induced nephrotoxicity and the results from studies of mineralocorticoid antagonism in renal transplant patients.

Original languageEnglish
Article number210
JournalFrontiers in Medicine
Volume4
Issue numberNOV
Number of pages8
ISSN2296-858X
DOIs
Publication statusPublished - 1. Jan 2017

Keywords

  • Aldosterone
  • Cyclosporine A
  • Fibrosis
  • IF/TA
  • Mineralocorticoid
  • Tacrolimus

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