Do Children of Long-Lived Parents Age More Successfully?

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND:
Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents.

METHODS:
We used three major cross-sectional population-based surveys to study the association of parental longevity with successful aging in offspring. The measures of aging were hand-grip strength, cognitive performance (Mini Mental State Examination and a cognitive composite score), self-reported diseases, and self-rated health.

RESULTS:
For every additional 10 years the parents lived, their children's grip strength increased by 0.32 kg (95% CI = 0.00-0.63), Mini Mental State Examination score by 0.20 points (95% CI = 0.03-0.37), and cognitive composite score by 0.24 points (95% CI = 0.07-0.40). A 10-year increment of parental life was associated with a reduction by approximately 0.20 in the adjusted odds ratio for their children having each of the following conditions: diabetes; hypertension; ischemic heart disease; heart failure; stroke; or fair, poor, or very poor self-rated health. Almost all the effects were seen solely in the cohort of 70+-year-olds, but not among middle-aged or nonagenarian subjects.

CONCLUSIONS:
Parental life span is positively associated with the children's physical and cognitive functioning and avoidance of some of the common chronic diseases. However, the effects are small and are seen among offspring who are elderly, but not among the middle-aged or the oldest old.
Original languageEnglish
JournalEpidemiology
Volume13
Issue number3
Pages (from-to)334-339
ISSN1044-3983
Publication statusPublished - 2002

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@article{302117b0ba9911dc9626000ea68e967b,
title = "Do Children of Long-Lived Parents Age More Successfully?",
abstract = "BACKGROUND:Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents.METHODS:We used three major cross-sectional population-based surveys to study the association of parental longevity with successful aging in offspring. The measures of aging were hand-grip strength, cognitive performance (Mini Mental State Examination and a cognitive composite score), self-reported diseases, and self-rated health.RESULTS:For every additional 10 years the parents lived, their children's grip strength increased by 0.32 kg (95{\%} CI = 0.00-0.63), Mini Mental State Examination score by 0.20 points (95{\%} CI = 0.03-0.37), and cognitive composite score by 0.24 points (95{\%} CI = 0.07-0.40). A 10-year increment of parental life was associated with a reduction by approximately 0.20 in the adjusted odds ratio for their children having each of the following conditions: diabetes; hypertension; ischemic heart disease; heart failure; stroke; or fair, poor, or very poor self-rated health. Almost all the effects were seen solely in the cohort of 70+-year-olds, but not among middle-aged or nonagenarian subjects.CONCLUSIONS:Parental life span is positively associated with the children's physical and cognitive functioning and avoidance of some of the common chronic diseases. However, the effects are small and are seen among offspring who are elderly, but not among the middle-aged or the oldest old.",
author = "Frederiksen, {Heidi B{\o}gelund} and Matt McGue and Bernard Jeune and David Gaist and Hanne Nybo and Axel Skytthe and Vaupel, {James W.} and Kaare Christensen",
year = "2002",
language = "English",
volume = "13",
pages = "334--339",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

Do Children of Long-Lived Parents Age More Successfully? / Frederiksen, Heidi Bøgelund; McGue, Matt; Jeune, Bernard; Gaist, David; Nybo, Hanne; Skytthe, Axel; Vaupel, James W.; Christensen, Kaare.

In: Epidemiology, Vol. 13, No. 3, 2002, p. 334-339.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Do Children of Long-Lived Parents Age More Successfully?

AU - Frederiksen, Heidi Bøgelund

AU - McGue, Matt

AU - Jeune, Bernard

AU - Gaist, David

AU - Nybo, Hanne

AU - Skytthe, Axel

AU - Vaupel, James W.

AU - Christensen, Kaare

PY - 2002

Y1 - 2002

N2 - BACKGROUND:Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents.METHODS:We used three major cross-sectional population-based surveys to study the association of parental longevity with successful aging in offspring. The measures of aging were hand-grip strength, cognitive performance (Mini Mental State Examination and a cognitive composite score), self-reported diseases, and self-rated health.RESULTS:For every additional 10 years the parents lived, their children's grip strength increased by 0.32 kg (95% CI = 0.00-0.63), Mini Mental State Examination score by 0.20 points (95% CI = 0.03-0.37), and cognitive composite score by 0.24 points (95% CI = 0.07-0.40). A 10-year increment of parental life was associated with a reduction by approximately 0.20 in the adjusted odds ratio for their children having each of the following conditions: diabetes; hypertension; ischemic heart disease; heart failure; stroke; or fair, poor, or very poor self-rated health. Almost all the effects were seen solely in the cohort of 70+-year-olds, but not among middle-aged or nonagenarian subjects.CONCLUSIONS:Parental life span is positively associated with the children's physical and cognitive functioning and avoidance of some of the common chronic diseases. However, the effects are small and are seen among offspring who are elderly, but not among the middle-aged or the oldest old.

AB - BACKGROUND:Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents.METHODS:We used three major cross-sectional population-based surveys to study the association of parental longevity with successful aging in offspring. The measures of aging were hand-grip strength, cognitive performance (Mini Mental State Examination and a cognitive composite score), self-reported diseases, and self-rated health.RESULTS:For every additional 10 years the parents lived, their children's grip strength increased by 0.32 kg (95% CI = 0.00-0.63), Mini Mental State Examination score by 0.20 points (95% CI = 0.03-0.37), and cognitive composite score by 0.24 points (95% CI = 0.07-0.40). A 10-year increment of parental life was associated with a reduction by approximately 0.20 in the adjusted odds ratio for their children having each of the following conditions: diabetes; hypertension; ischemic heart disease; heart failure; stroke; or fair, poor, or very poor self-rated health. Almost all the effects were seen solely in the cohort of 70+-year-olds, but not among middle-aged or nonagenarian subjects.CONCLUSIONS:Parental life span is positively associated with the children's physical and cognitive functioning and avoidance of some of the common chronic diseases. However, the effects are small and are seen among offspring who are elderly, but not among the middle-aged or the oldest old.

M3 - Journal article

VL - 13

SP - 334

EP - 339

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 3

ER -