Disulphide bridges of bovine factor X

P Højrup, S Magnusson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Evidence is presented for the disulphide bridges in bovine Factor X. The protein was degraded by chemical and enzymic means, and all 12 disulphide bridges were isolated in separate peptides except for bridges nos. 6/7 in the light chain. All the disulphide bridges were found to be in positions corresponding to those found in other homologous domains. This report is the first verification of an epidermal-growth-factor-homologous domain having the same disulphide-bonding pattern as that found in mouse epidermal growth factor.

Original languageEnglish
JournalThe Biochemical journal
Volume245
Issue number3
Pages (from-to)887-91
Number of pages5
ISSN0264-6021
DOIs
Publication statusPublished - 1. Aug 1987

Keywords

  • Amino Acids/analysis
  • Animals
  • Cattle
  • Disulfides/analysis
  • Factor X
  • Peptide Fragments/analysis

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