Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma

Marcus Høy Hansen*, Karen Juul-Jensen, Oriane Cédile, Stephanie Kavan, Michael Boe Møller, Jacob Haaber, Charlotte Guldborg Nyvold

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Relapse involving the central nervous system (CNS) is an infrequent event in the progression of mantle cell lymphoma (MCL) with an incidence of approximately four percent. We report four cases of MCL with CNS relapse. In three of the four patients a large chromosomal copy-number alteration (CNA) of 1q was demonstrated together with TP53 mutation/deletion. These patients experienced brief response to ibrutinib, whereas a fourth patient harboring mutated ATM demonstrated a long-term effect to ibrutinib and no CNA. Although it is unclear whether chromosome 1q CNA contribute to specific phenotypes these reports may be of value as such lesions are uncommon features of MCL.

Original languageEnglish
Article number100255
JournalLeukemia Research Reports
Volume15
Number of pages5
ISSN2213-0489
DOIs
Publication statusPublished - Jan 2021

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Central nervous system relapse
  • Chromosome 1 aberration
  • Copy number alteration
  • Ibrutinib response
  • Mantle cell lymphoma

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