DIGGER: exploring the functional role of alternative splicing in protein interactions

Zakaria Louadi, Kevin Yuan, Alexander Gress, Olga Tsoy, Olga V. Kalinina, Jan Baumbach, Tim Kacprowski*, Markus List*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.

Original languageEnglish
JournalNucleic acids research
Volume49
Issue numberD1
Pages (from-to)D309-D318
ISSN0305-1048
DOIs
Publication statusPublished - 8. Jan 2021

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