Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements

Gergely Orsi, Mihály Aradi, Szilvia Anett Nagy, Gábor Perlaki, Anita Trauninger, Péter Bogner, József Janszky, Zsolt Illés, Tamás Dóczi, Zoltán Pfund, Attila Schwarcz

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Abstract

PURPOSE: To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements.

MATERIALS AND METHODS: Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm(2) ) and biexponential (0-5000 s/mm(2) ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls.

RESULTS: High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 × 10(-4) mm(2) /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10(-4) mm(2) /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively).

CONCLUSION: Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.

Original languageEnglish
JournalJournal of Magnetic Resonance Imaging
Volume41
Issue number3
Pages (from-to)676-83
ISSN1053-1807
DOIs
Publication statusPublished - Mar 2015
Externally publishedYes

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Orsi, Gergely ; Aradi, Mihály ; Nagy, Szilvia Anett ; Perlaki, Gábor ; Trauninger, Anita ; Bogner, Péter ; Janszky, József ; Illés, Zsolt ; Dóczi, Tamás ; Pfund, Zoltán ; Schwarcz, Attila. / Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements. In: Journal of Magnetic Resonance Imaging. 2015 ; Vol. 41, No. 3. pp. 676-83.
@article{aa0c1ddd73df4b8e9febcbe6a07ecb80,
title = "Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements",
abstract = "PURPOSE: To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements.MATERIALS AND METHODS: Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm(2) ) and biexponential (0-5000 s/mm(2) ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls.RESULTS: High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 × 10(-4) mm(2) /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10(-4) mm(2) /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively).CONCLUSION: Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.",
author = "Gergely Orsi and Mih{\'a}ly Aradi and Nagy, {Szilvia Anett} and G{\'a}bor Perlaki and Anita Trauninger and P{\'e}ter Bogner and J{\'o}zsef Janszky and Zsolt Ill{\'e}s and Tam{\'a}s D{\'o}czi and Zolt{\'a}n Pfund and Attila Schwarcz",
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year = "2015",
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doi = "10.1002/jmri.24580",
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Orsi, G, Aradi, M, Nagy, SA, Perlaki, G, Trauninger, A, Bogner, P, Janszky, J, Illés, Z, Dóczi, T, Pfund, Z & Schwarcz, A 2015, 'Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements', Journal of Magnetic Resonance Imaging, vol. 41, no. 3, pp. 676-83. https://doi.org/10.1002/jmri.24580

Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements. / Orsi, Gergely; Aradi, Mihály; Nagy, Szilvia Anett; Perlaki, Gábor; Trauninger, Anita; Bogner, Péter; Janszky, József; Illés, Zsolt; Dóczi, Tamás; Pfund, Zoltán; Schwarcz, Attila.

In: Journal of Magnetic Resonance Imaging, Vol. 41, No. 3, 03.2015, p. 676-83.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Differentiating white matter lesions in multiple sclerosis and migraine using monoexponential and biexponential diffusion measurements

AU - Orsi, Gergely

AU - Aradi, Mihály

AU - Nagy, Szilvia Anett

AU - Perlaki, Gábor

AU - Trauninger, Anita

AU - Bogner, Péter

AU - Janszky, József

AU - Illés, Zsolt

AU - Dóczi, Tamás

AU - Pfund, Zoltán

AU - Schwarcz, Attila

N1 - © 2014 Wiley Periodicals, Inc.

PY - 2015/3

Y1 - 2015/3

N2 - PURPOSE: To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements.MATERIALS AND METHODS: Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm(2) ) and biexponential (0-5000 s/mm(2) ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls.RESULTS: High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 × 10(-4) mm(2) /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10(-4) mm(2) /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively).CONCLUSION: Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.

AB - PURPOSE: To compare the white matter lesions seen in multiple sclerosis and migraine using monoexponential and high b-value biexponential diffusion measurements.MATERIALS AND METHODS: Diffusion-weighted images were acquired on a 3.0-Tesla magnetic resonance imaging system. Diffusion parameters were estimated using monoexponential (0-1000 s/mm(2) ) and biexponential (0-5000 s/mm(2) ) approaches from 15 multiple sclerosis patients, 15 patients with migraine and 15 healthy control subjects. The study was performed in accordance with the approval of the Regional Research Ethics Committee. The apparent diffusion coefficient (ADC) values were measured in the lesions and the normal-appearing white matter of patients and in the white matter of controls.RESULTS: High lesional ADCmono values were detected in both patient groups without significant differences between the groups (10.72 and 9.86 × 10(-4) mm(2) /s for MS and migraine respectively, P = 0.2134). The biexponential measurements showed significantly higher ADCfast , ADCslow , and Pslow values in the migraine lesions than in the multiple sclerosis lesions (16.47 versus 14.29, 1.41 versus 0.76, and 20.34 versus 12.01 all values in 10(-4) mm(2) /s; P = 0.0344, P = 0.0019, P = 0.0021, respectively).CONCLUSION: Biexponential diffusion analysis may help to differentiate multiple sclerosis-related white matter lesions from migraine-related ones.

U2 - 10.1002/jmri.24580

DO - 10.1002/jmri.24580

M3 - Journal article

C2 - 24677284

VL - 41

SP - 676

EP - 683

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -