Different Causes of Death in Patients with Myocardial Infarction Type 1, Type 2 and Myocardial Injury

S Lambrecht, Laura Sarkisian, Lotte Saaby, Tina S Poulsen, Oke Gerke, Susanne Hosbond, Axel C P Diederichsen, Kristian Thygesen, Hans Mickley

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Data outlining the mortality and the causes of death in patients with type 1 myocardial infarction, type 2 myocardial infarction, and those with myocardial injury are limited. Methods: During a 1-year period from January 2010 to January 2011, all hospitalized patients who had cardiac troponin I measured on clinical indication were prospectively studied. Patients with at least one cardiac troponin I value >30 ng/L underwent case ascertainment and individual evaluation by an experienced adjudication committee. Patients were classified as having type 1 myocardial infarction, type 2 myocardial infarction, or myocardial injury according to the criteria of the universal definition of myocardial infarction. Follow-up was ensured until December 31, 2014. Data on mortality and causes of death were obtained from the Danish Civil Registration System and the Danish Register of Causes of Death. Results: Overall, 3762 consecutive patients were followed for a mean of 3.2 years (interquartile range 1.3-3.6 years). All-cause mortality differed significantly among categories: Type 1 myocardial infarction 31.7%, type 2 myocardial infarction 62.2%, myocardial injury 58.7%, and 22.2% in patients with nonelevated troponin values (log-rank test; P <.0001). In patients with type 1 myocardial infarction, 61.3% died from cardiovascular causes, vs 42.6% in patients with type 2 myocardial infarction (P =.015) and 41.2% in those with myocardial injury (P <.0001). The overall mortality and the causes of death did not differ substantially between patients with type 2 myocardial infarction and those with myocardial injury. Conclusions: Patients with type 2 myocardial infarction and myocardial injury exhibit a significantly higher long-term mortality compared with patients with type 1 myocardial infarction. However, most patients with type 1 myocardial infarction die from cardiovascular causes in contrast to patients with type 2 myocardial infarction and myocardial injury, in whom noncardiovascular causes of death predominate.

Original languageEnglish
JournalAmerican Journal of Medicine
Volume131
Issue number5
Pages (from-to)548-554
ISSN0002-9343
DOIs
Publication statusPublished - May 2018

Bibliographical note

Copyright © 2018 Elsevier Inc. All rights reserved.

Keywords

  • Causes of death
  • Myocardial injury
  • Troponin
  • Type 1 myocardial infarction
  • Type 2 myocardial infarction

Fingerprint

Dive into the research topics of 'Different Causes of Death in Patients with Myocardial Infarction Type 1, Type 2 and Myocardial Injury'. Together they form a unique fingerprint.

Cite this