Differences in current clinical features of diploid and triploid hydatidiform mole

I Niemann, L K Petersen, E S Hansen, L Sunde

Research output: Contribution to journalJournal articleResearchpeer-review


OBJECTIVE: To describe and compare the current clinical features of diploid and triploid molar pregnancy and to evaluate whether the presenting clinical features can predict the ploidy of a molar pregnancy.

DESIGN: A retrospective study of the clinical features and ploidy of hydatidiform moles.

SETTING: The Departments of Clinical Genetics and Pathology, Aarhus University Hospital and 13 gynaecological wards, Jutland, Denmark.

POPULATION: A total of 259 women with molar pregnancy diagnosed between April 1986 and June 2003.

METHODS: A review of medical records of consecutively collected, clinically suspected cases of molar pregnancy was performed. The molar ploidy was determined by karyotyping, flow cytometry, and/or analysis of polymorphic DNA markers.

MAIN OUTCOME MEASURES: Maternal characteristics, presenting symptoms, initial human chorionic gonadotrophin (hCG), and molar ploidy.

RESULTS: In a multiple logistic regression model, initial hCG of > or = 100,000 iu/l (P < 0.001), first-trimester gestational age (P < 0.001), vaginal bleeding (P < 0.001), and maternal age of > or = 40 years (P = 0.03) were independent predictors of diploid mole. Women with excessive uterine size more frequently had a diploid than a triploid mole (P < 0.001). Fifty-four percent of the women with triploid mole and 27% of the women with diploid mole were diagnosed before onset of symptoms (P < 0.001).

CONCLUSIONS: The current clinical features of diploid mole are different from those of triploid mole. The presenting clinical profile of a molar pregnancy may be used as an early predictor of the molar ploidy and thus of the prognosis.

Original languageEnglish
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number10
Pages (from-to)1273-7
Number of pages5
Publication statusPublished - Oct 2007


  • Adolescent
  • Adult
  • Chorionic Gonadotropin/metabolism
  • Female
  • Gravidity
  • Humans
  • Hydatidiform Mole/blood
  • Logistic Models
  • Middle Aged
  • Ploidies
  • Pregnancy
  • Retrospective Studies
  • Uterine Hemorrhage/etiology
  • Uterine Neoplasms/blood


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