Dietary arginine and linear growth: the Copenhagen School Child Intervention Study

Anneke J A H van Vught, Pieter C Dagnelie, Ilja C W Arts, Karsten Froberg, Lars Bo Andersen, Bianca El-Naaman, Anna Bugge, Birgit M. Nielsen, Berit Lilienthal Heitmann

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The amino acid arginine is a well-known growth hormone (GH) stimulator and GH is an important modulator of linear growth. The aim of the present study was to investigate the effect of dietary arginine on growth velocity in children between 7 and 13 years of age. Data from the Copenhagen School Child Intervention Study during 2001-2 (baseline), and at 3-year and 7-year follow-up, were used. Arginine intake was estimated via a 7 d precoded food diary at baseline and 3-year follow-up. Data were analysed in a multilevel structure in which children were embedded within schools. Random intercept and slopes were defined to estimate the association between arginine intake and growth velocity, including the following covariates: sex; age; baseline height; energy intake; puberty stage at 7-year follow-up and intervention/control group. The association between arginine intake and growth velocity was significant for the third and fourth quintile of arginine intake (2·5-2·8 and 2·8-3·2 g/d, respectively) compared with the first quintile ( 
Original languageEnglish
JournalBritish Journal of Nutrition
Volume109
Issue number6
Pages (from-to)1031-1039
Number of pages9
ISSN0007-1145
DOIs
Publication statusPublished - Mar 2013

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