Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis

diagnostic implications in Alzheimer’s disease and mild cognitive impairment

Eivind Antonsen Segtnan, Alireza Majdi, Caius Mihail Constantinescu, Peter Grupe, Oke Gerke, Heini Tórstún í Dali, Olaf Emil Strøm, Jorun Holm, Abass Alavi, Saeed Sadigh-Eteghad, Lene Wermuth, Malene Hildebrandt, Albert Gjedde, Poul Flemming Høilund-Carlsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Methods: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50–78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Ten neurologically healthy individuals (HIs) (mean age 62.5 years, range 43–75, 5 females) served as controls. A neuroimaging expert provided visual assessment of diaschisis. The total hemispheric glucose metabolism ratio (THGr) was calculated, and with area-under the curve of receiver operating characteristics (AUC-ROC) we generated a “Network Diaschisis Test (NDT)”. Results: The qualitative detection of cerebral (Ce) and cerebellar (Cb) diaschisis was 7/15 (47%), 0/8 (0%), and 0/10 (0%) in AD, MCI, and HI groups, respectively. Median cerebral THGr was 0.68 (range 0.43–0.99), 0.86 (range 0.64–0.98), and 0.95 (range 0.65–1.00) for AD, MCI, and HI groups, respectively (p = 0.04). Median cerebellar THGr was, respectively, 0.70 (range 0.18–0.98), 0.70 (range 0.48–0.81), and 0.84 (range 0.75–0.96) (p = 0.0138). A positive NDT yielded a positive predictive value of 100% for the presence of AD or MCI and a 86% negative predictive value for healthy brain. Moreover, the diagnostic manifestation of THGr between MCI and AD led to a positive predictive value of 100% for AD, but a negative predictive value of 42.9% for MCI. Conclusion: Patients with AD or MCI had more pronounced diaschisis, lateralized hemispheric glucose metabolism and lower THGr compared to healthy controls. The NDT distinguished AD and MCI patients from HIs, and AD from MCI patients with a high positive predictive value and moderate and low negative predictive values. THGr can be a straightforward source of investigating neuronal network diaschisis in AD and MCI and in other cerebral diseases, across institutions.

Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume46
Issue number5
Pages (from-to)1164-1174
ISSN1619-7070
DOIs
Publication statusPublished - May 2019

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Alzheimer Disease
Cognitive Dysfunction
Neuroimaging
ROC Curve
Area Under Curve

Keywords

  • Diaschisis
  • Neuronal network
  • FDG-PET/CT
  • Alzheimer's disease
  • Mild Cognitive Impairment
  • Alzheimer’s disease
  • Mild cognitive impairment

Cite this

@article{fb8c7734dcc64fa98a915ba6a5ce1d35,
title = "Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis: diagnostic implications in Alzheimer’s disease and mild cognitive impairment",
abstract = "Purpose: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Methods: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50–78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Ten neurologically healthy individuals (HIs) (mean age 62.5 years, range 43–75, 5 females) served as controls. A neuroimaging expert provided visual assessment of diaschisis. The total hemispheric glucose metabolism ratio (THGr) was calculated, and with area-under the curve of receiver operating characteristics (AUC-ROC) we generated a “Network Diaschisis Test (NDT)”. Results: The qualitative detection of cerebral (Ce) and cerebellar (Cb) diaschisis was 7/15 (47{\%}), 0/8 (0{\%}), and 0/10 (0{\%}) in AD, MCI, and HI groups, respectively. Median cerebral THGr was 0.68 (range 0.43–0.99), 0.86 (range 0.64–0.98), and 0.95 (range 0.65–1.00) for AD, MCI, and HI groups, respectively (p = 0.04). Median cerebellar THGr was, respectively, 0.70 (range 0.18–0.98), 0.70 (range 0.48–0.81), and 0.84 (range 0.75–0.96) (p = 0.0138). A positive NDT yielded a positive predictive value of 100{\%} for the presence of AD or MCI and a 86{\%} negative predictive value for healthy brain. Moreover, the diagnostic manifestation of THGr between MCI and AD led to a positive predictive value of 100{\%} for AD, but a negative predictive value of 42.9{\%} for MCI. Conclusion: Patients with AD or MCI had more pronounced diaschisis, lateralized hemispheric glucose metabolism and lower THGr compared to healthy controls. The NDT distinguished AD and MCI patients from HIs, and AD from MCI patients with a high positive predictive value and moderate and low negative predictive values. THGr can be a straightforward source of investigating neuronal network diaschisis in AD and MCI and in other cerebral diseases, across institutions.",
keywords = "Diaschisis, Neuronal network, FDG-PET/CT, Alzheimer's disease, Mild Cognitive Impairment, Alzheimer’s disease, Mild cognitive impairment",
author = "{Antonsen Segtnan}, Eivind and Alireza Majdi and Constantinescu, {Caius Mihail} and Peter Grupe and Oke Gerke and Dali, {Heini T{\'o}rst{\'u}n {\'i}} and Str{\o}m, {Olaf Emil} and Jorun Holm and Abass Alavi and Saeed Sadigh-Eteghad and Lene Wermuth and Malene Hildebrandt and Albert Gjedde and H{\o}ilund-Carlsen, {Poul Flemming}",
year = "2019",
month = "5",
doi = "10.1007/s00259-018-4248-0",
language = "English",
volume = "46",
pages = "1164--1174",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Heinemann",
number = "5",

}

Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis : diagnostic implications in Alzheimer’s disease and mild cognitive impairment. / Antonsen Segtnan, Eivind; Majdi, Alireza; Constantinescu, Caius Mihail; Grupe, Peter; Gerke, Oke; Dali, Heini Tórstún í; Strøm, Olaf Emil ; Holm, Jorun; Alavi, Abass; Sadigh-Eteghad, Saeed; Wermuth, Lene; Hildebrandt, Malene ; Gjedde, Albert; Høilund-Carlsen, Poul Flemming.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 46, No. 5, 05.2019, p. 1164-1174.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis

T2 - diagnostic implications in Alzheimer’s disease and mild cognitive impairment

AU - Antonsen Segtnan, Eivind

AU - Majdi, Alireza

AU - Constantinescu, Caius Mihail

AU - Grupe, Peter

AU - Gerke, Oke

AU - Dali, Heini Tórstún í

AU - Strøm, Olaf Emil

AU - Holm, Jorun

AU - Alavi, Abass

AU - Sadigh-Eteghad, Saeed

AU - Wermuth, Lene

AU - Hildebrandt, Malene

AU - Gjedde, Albert

AU - Høilund-Carlsen, Poul Flemming

PY - 2019/5

Y1 - 2019/5

N2 - Purpose: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Methods: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50–78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Ten neurologically healthy individuals (HIs) (mean age 62.5 years, range 43–75, 5 females) served as controls. A neuroimaging expert provided visual assessment of diaschisis. The total hemispheric glucose metabolism ratio (THGr) was calculated, and with area-under the curve of receiver operating characteristics (AUC-ROC) we generated a “Network Diaschisis Test (NDT)”. Results: The qualitative detection of cerebral (Ce) and cerebellar (Cb) diaschisis was 7/15 (47%), 0/8 (0%), and 0/10 (0%) in AD, MCI, and HI groups, respectively. Median cerebral THGr was 0.68 (range 0.43–0.99), 0.86 (range 0.64–0.98), and 0.95 (range 0.65–1.00) for AD, MCI, and HI groups, respectively (p = 0.04). Median cerebellar THGr was, respectively, 0.70 (range 0.18–0.98), 0.70 (range 0.48–0.81), and 0.84 (range 0.75–0.96) (p = 0.0138). A positive NDT yielded a positive predictive value of 100% for the presence of AD or MCI and a 86% negative predictive value for healthy brain. Moreover, the diagnostic manifestation of THGr between MCI and AD led to a positive predictive value of 100% for AD, but a negative predictive value of 42.9% for MCI. Conclusion: Patients with AD or MCI had more pronounced diaschisis, lateralized hemispheric glucose metabolism and lower THGr compared to healthy controls. The NDT distinguished AD and MCI patients from HIs, and AD from MCI patients with a high positive predictive value and moderate and low negative predictive values. THGr can be a straightforward source of investigating neuronal network diaschisis in AD and MCI and in other cerebral diseases, across institutions.

AB - Purpose: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Methods: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50–78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Ten neurologically healthy individuals (HIs) (mean age 62.5 years, range 43–75, 5 females) served as controls. A neuroimaging expert provided visual assessment of diaschisis. The total hemispheric glucose metabolism ratio (THGr) was calculated, and with area-under the curve of receiver operating characteristics (AUC-ROC) we generated a “Network Diaschisis Test (NDT)”. Results: The qualitative detection of cerebral (Ce) and cerebellar (Cb) diaschisis was 7/15 (47%), 0/8 (0%), and 0/10 (0%) in AD, MCI, and HI groups, respectively. Median cerebral THGr was 0.68 (range 0.43–0.99), 0.86 (range 0.64–0.98), and 0.95 (range 0.65–1.00) for AD, MCI, and HI groups, respectively (p = 0.04). Median cerebellar THGr was, respectively, 0.70 (range 0.18–0.98), 0.70 (range 0.48–0.81), and 0.84 (range 0.75–0.96) (p = 0.0138). A positive NDT yielded a positive predictive value of 100% for the presence of AD or MCI and a 86% negative predictive value for healthy brain. Moreover, the diagnostic manifestation of THGr between MCI and AD led to a positive predictive value of 100% for AD, but a negative predictive value of 42.9% for MCI. Conclusion: Patients with AD or MCI had more pronounced diaschisis, lateralized hemispheric glucose metabolism and lower THGr compared to healthy controls. The NDT distinguished AD and MCI patients from HIs, and AD from MCI patients with a high positive predictive value and moderate and low negative predictive values. THGr can be a straightforward source of investigating neuronal network diaschisis in AD and MCI and in other cerebral diseases, across institutions.

KW - Diaschisis

KW - Neuronal network

KW - FDG-PET/CT

KW - Alzheimer's disease

KW - Mild Cognitive Impairment

KW - Alzheimer’s disease

KW - Mild cognitive impairment

U2 - 10.1007/s00259-018-4248-0

DO - 10.1007/s00259-018-4248-0

M3 - Journal article

VL - 46

SP - 1164

EP - 1174

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 5

ER -