Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes

Sandra Sif Gylfadottir, Diana Hedevang Christensen, Sia Kromann Nicolaisen, Henning Andersen, Brian Christopher Callaghan, Mustapha Itani, Karolina Snopek Khan, Alexander Gramm Kristensen, Jens Steen Nielsen, Søren Hein Sindrup, Niels Trolle Andersen, Troels Staehelin Jensen, Reimar Wernich Thomsen, Nanna Brix Finnerup

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥4 on the MNSI questionnaire determined possible DPN, whereas pain presence in both feet together with a score ≥3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, body mass index, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (odds ratio 1.52 [95% confidence interval: 1.20-1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality of life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.

Original languageEnglish
JournalPain
Volume161
Issue number3
Pages (from-to)574-583
ISSN0304-3959
DOIs
Publication statusPublished - Mar 2020

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Diabetic Neuropathies
Type 2 Diabetes Mellitus
Cross-Sectional Studies
Surveys and Questionnaires
Mental Health Associations
Smoking
Mental Health

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Gylfadottir, Sandra Sif ; Christensen, Diana Hedevang ; Nicolaisen, Sia Kromann ; Andersen, Henning ; Callaghan, Brian Christopher ; Itani, Mustapha ; Khan, Karolina Snopek ; Kristensen, Alexander Gramm ; Nielsen, Jens Steen ; Sindrup, Søren Hein ; Andersen, Niels Trolle ; Jensen, Troels Staehelin ; Thomsen, Reimar Wernich ; Finnerup, Nanna Brix. / Diabetic polyneuropathy and pain, prevalence, and patient characteristics : a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. In: Pain. 2020 ; Vol. 161, No. 3. pp. 574-583.
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title = "Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes",
abstract = "Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5514 (82{\%}) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥4 on the MNSI questionnaire determined possible DPN, whereas pain presence in both feet together with a score ≥3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18{\%} and 10{\%}, respectively. Female sex, age, diabetes duration, body mass index, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (odds ratio 1.52 [95{\%} confidence interval: 1.20-1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality of life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.",
author = "Gylfadottir, {Sandra Sif} and Christensen, {Diana Hedevang} and Nicolaisen, {Sia Kromann} and Henning Andersen and Callaghan, {Brian Christopher} and Mustapha Itani and Khan, {Karolina Snopek} and Kristensen, {Alexander Gramm} and Nielsen, {Jens Steen} and Sindrup, {S{\o}ren Hein} and Andersen, {Niels Trolle} and Jensen, {Troels Staehelin} and Thomsen, {Reimar Wernich} and Finnerup, {Nanna Brix}",
year = "2020",
month = "3",
doi = "10.1097/j.pain.0000000000001744",
language = "English",
volume = "161",
pages = "574--583",
journal = "Pain",
issn = "0304-3959",
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Gylfadottir, SS, Christensen, DH, Nicolaisen, SK, Andersen, H, Callaghan, BC, Itani, M, Khan, KS, Kristensen, AG, Nielsen, JS, Sindrup, SH, Andersen, NT, Jensen, TS, Thomsen, RW & Finnerup, NB 2020, 'Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes', Pain, vol. 161, no. 3, pp. 574-583. https://doi.org/10.1097/j.pain.0000000000001744

Diabetic polyneuropathy and pain, prevalence, and patient characteristics : a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. / Gylfadottir, Sandra Sif; Christensen, Diana Hedevang; Nicolaisen, Sia Kromann; Andersen, Henning; Callaghan, Brian Christopher; Itani, Mustapha; Khan, Karolina Snopek; Kristensen, Alexander Gramm; Nielsen, Jens Steen; Sindrup, Søren Hein; Andersen, Niels Trolle; Jensen, Troels Staehelin; Thomsen, Reimar Wernich; Finnerup, Nanna Brix.

In: Pain, Vol. 161, No. 3, 03.2020, p. 574-583.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Diabetic polyneuropathy and pain, prevalence, and patient characteristics

T2 - a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes

AU - Gylfadottir, Sandra Sif

AU - Christensen, Diana Hedevang

AU - Nicolaisen, Sia Kromann

AU - Andersen, Henning

AU - Callaghan, Brian Christopher

AU - Itani, Mustapha

AU - Khan, Karolina Snopek

AU - Kristensen, Alexander Gramm

AU - Nielsen, Jens Steen

AU - Sindrup, Søren Hein

AU - Andersen, Niels Trolle

AU - Jensen, Troels Staehelin

AU - Thomsen, Reimar Wernich

AU - Finnerup, Nanna Brix

PY - 2020/3

Y1 - 2020/3

N2 - Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥4 on the MNSI questionnaire determined possible DPN, whereas pain presence in both feet together with a score ≥3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, body mass index, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (odds ratio 1.52 [95% confidence interval: 1.20-1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality of life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.

AB - Most studies of diabetic polyneuropathy (DPN) and painful DPN are conducted in persons with longstanding diabetes. This cross-sectional study aimed to estimate the prevalence of DPN and painful DPN, important risk factors, and the association with mental health in recently diagnosed type 2 diabetes. A total of 5514 (82%) patients (median diabetes duration 4.6 years) enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort responded to a detailed questionnaire on neuropathy and pain. A score ≥4 on the MNSI questionnaire determined possible DPN, whereas pain presence in both feet together with a score ≥3 on the DN4 questionnaire determined possible painful DPN. The prevalence of possible DPN and possible painful DPN was 18% and 10%, respectively. Female sex, age, diabetes duration, body mass index, and smoking were associated with possible DPN, whereas only smoking showed a clear association with possible painful DPN (odds ratio 1.52 [95% confidence interval: 1.20-1.93]). Possible DPN and painful DPN were independently and additively associated with lower quality of life, poorer sleep, and symptoms of depression and anxiety. Possible DPN itself had greater impact on mental health than neuropathic pain. This large study emphasizes the importance of careful screening for DPN and pain early in the course of type 2 diabetes.

U2 - 10.1097/j.pain.0000000000001744

DO - 10.1097/j.pain.0000000000001744

M3 - Journal article

C2 - 31693539

VL - 161

SP - 574

EP - 583

JO - Pain

JF - Pain

SN - 0304-3959

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ER -