Developmental milestones in post-term born children

Annette Wind Olesen, Jørn Olsen, Jinliang Zhu

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Annette Wind Olesen (1), Jorn Olsen (2), Jinliang Zhu (2)
(1)Institute of Regional Health Research, University of Southern Denmark, (2)The Danish Epidemiology Science Centre, Aarhus University

Objective: To examine the timing of reaching developmental milestones in children born post-term.
Design: Cohort study.
Material: The Danish National Birth Cohort; children born between 1997 and 2003. Data was obtained from a
cohort of 92,892 pregnancies participating in the first pregnancy interview. All singletons born in gestational week
39-45 were identified. The study was then restricted to children who participated in an interview at age of
approximately 18 months and had information on at least one developmental milestone, e.g. sitting without
support, using two word sentences. We excluded children of mothers with chronic diseases from the final analysis.
The remaining study population constituted of 43915 singletons (27503 born at term, 16412 born post-term).
Methods: Logistic regression was used to calculate odds ratios of late achievement of these developmental
milestones adjusted for potential confounding factors.
Main outcome measures: Achieving developmental milestones at the time of interview or certain age.
Results: More children born post-term achieved the assessed developmental milestones compared with children
born at term (39-40 weeks). Test for trend for gestational ages 39, 40 and 41 weeks also showed a positive trend at
achieving developmental milestones with gestational age at birth in 9 out of 14 milestone items.
Conclusion: Post-term born children appear to reach the main developmental milestones at an earlier age since
birth than term born children. The association could also be due to bias related to a longer time between conception
and interviewing, misclassification of endpoints or selection bias.
Keywords: Developmental milestones, gestational age, post-term, Danish National Birth Cohort
Original languageEnglish
Publication date4. Nov 2015
Publication statusPublished - 4. Nov 2015
Event12th World Congress of Perinatal Medicine - Madrid, Spain
Duration: 3. Nov 20156. Nov 2015
Conference number: 12th


Conference12th World Congress of Perinatal Medicine

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