Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method

Pernille Hededal, Mikkel Østergaard, Inge Juul Sørensen, Anne Gitte Loft, Jens S Hindrup, Gorm Thamsborg, Karsten Asmussen, Oliver Hendricks, Jesper Nørregaard, Jakob M Møller, Anne Grethe Jurik, Lone Morsel, Lone Balding, Susanne Juhl Pedersen

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Abstract

OBJECTIVE: To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods.

METHODS: Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)].

RESULTS: Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83-0.88 and 0.85-0.97; change 0.33-0.78), while high to very high for semicoronal scoring methods (baseline 0.90-0.92 and 0.93-0.97; change 0.77-0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R(2) = 0.93 and 0.88; change: R(2) = 0.82 and 0.87, respectively), while lower for the global method (baseline: R(2) = 0.79; change: R(2) = 0.54). The SDC-HOS were 9.8-18.6% and 5.9-10.7% for the semiaxial and semicoronal methods, respectively.

CONCLUSION: Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.

Original languageEnglish
JournalJournal of Rheumatology
Volume45
Issue number1
Pages (from-to)70-77
ISSN0315-162X
DOIs
Publication statusPublished - 2018

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Hededal, Pernille ; Østergaard, Mikkel ; Sørensen, Inge Juul ; Loft, Anne Gitte ; Hindrup, Jens S ; Thamsborg, Gorm ; Asmussen, Karsten ; Hendricks, Oliver ; Nørregaard, Jesper ; Møller, Jakob M ; Jurik, Anne Grethe ; Morsel, Lone ; Balding, Lone ; Pedersen, Susanne Juhl. / Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method. In: Journal of Rheumatology. 2018 ; Vol. 45, No. 1. pp. 70-77.
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title = "Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method",
abstract = "OBJECTIVE: To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods.METHODS: Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)].RESULTS: Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83-0.88 and 0.85-0.97; change 0.33-0.78), while high to very high for semicoronal scoring methods (baseline 0.90-0.92 and 0.93-0.97; change 0.77-0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R(2) = 0.93 and 0.88; change: R(2) = 0.82 and 0.87, respectively), while lower for the global method (baseline: R(2) = 0.79; change: R(2) = 0.54). The SDC-HOS were 9.8-18.6{\%} and 5.9-10.7{\%} for the semiaxial and semicoronal methods, respectively.CONCLUSION: Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.",
keywords = "Journal Article",
author = "Pernille Hededal and Mikkel {\O}stergaard and S{\o}rensen, {Inge Juul} and Loft, {Anne Gitte} and Hindrup, {Jens S} and Gorm Thamsborg and Karsten Asmussen and Oliver Hendricks and Jesper N{\o}rregaard and M{\o}ller, {Jakob M} and Jurik, {Anne Grethe} and Lone Morsel and Lone Balding and Pedersen, {Susanne Juhl}",
year = "2018",
doi = "10.3899/jrheum.161583",
language = "English",
volume = "45",
pages = "70--77",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "1",

}

Hededal, P, Østergaard, M, Sørensen, IJ, Loft, AG, Hindrup, JS, Thamsborg, G, Asmussen, K, Hendricks, O, Nørregaard, J, Møller, JM, Jurik, AG, Morsel, L, Balding, L & Pedersen, SJ 2018, 'Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method', Journal of Rheumatology, vol. 45, no. 1, pp. 70-77. https://doi.org/10.3899/jrheum.161583

Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method. / Hededal, Pernille; Østergaard, Mikkel; Sørensen, Inge Juul; Loft, Anne Gitte; Hindrup, Jens S; Thamsborg, Gorm; Asmussen, Karsten; Hendricks, Oliver; Nørregaard, Jesper; Møller, Jakob M; Jurik, Anne Grethe; Morsel, Lone; Balding, Lone; Pedersen, Susanne Juhl.

In: Journal of Rheumatology, Vol. 45, No. 1, 2018, p. 70-77.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method

AU - Hededal, Pernille

AU - Østergaard, Mikkel

AU - Sørensen, Inge Juul

AU - Loft, Anne Gitte

AU - Hindrup, Jens S

AU - Thamsborg, Gorm

AU - Asmussen, Karsten

AU - Hendricks, Oliver

AU - Nørregaard, Jesper

AU - Møller, Jakob M

AU - Jurik, Anne Grethe

AU - Morsel, Lone

AU - Balding, Lone

AU - Pedersen, Susanne Juhl

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods.METHODS: Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)].RESULTS: Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83-0.88 and 0.85-0.97; change 0.33-0.78), while high to very high for semicoronal scoring methods (baseline 0.90-0.92 and 0.93-0.97; change 0.77-0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R(2) = 0.93 and 0.88; change: R(2) = 0.82 and 0.87, respectively), while lower for the global method (baseline: R(2) = 0.79; change: R(2) = 0.54). The SDC-HOS were 9.8-18.6% and 5.9-10.7% for the semiaxial and semicoronal methods, respectively.CONCLUSION: Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.

AB - OBJECTIVE: To develop semiaxial magnetic resonance imaging (MRI) scoring methods for assessment of sacroiliac joint (SIJ) bone marrow edema (BME) in patients with axial spondyloarthritis, and to compare the reliability with equivalent semicoronal scoring methods.METHODS: Two semiaxial SIJ MRI scoring methods were developed based on the principles of the semicoronal Berlin and Spondyloarthritis Research Consortium of Canada (SPARCC) methods. A global quadrant-based method was also developed. Baseline and 12-week MRI of the SIJ from 51 patients participating in a randomized double-blind placebo-controlled trial of adalimumab 40 mg every other week versus placebo were scored by the semiaxial and the corresponding semicoronal methods. Results were compared by linear regression analysis. The reproducibility and sensitivity were evaluated by intraclass correlation coefficients (ICC) and smallest detectable change [SDC, absolute values and percentage of the highest observed score (SDC-HOS)].RESULTS: Interreader and intrareader ICC were moderate to very high for semiaxial scoring methods (baseline 0.83-0.88 and 0.85-0.97; change 0.33-0.78), while high to very high for semicoronal scoring methods (baseline 0.90-0.92 and 0.93-0.97; change 0.77-0.89). Association between semiaxial and semicoronal scores were high for both the Berlin and SPARCC method (baseline: R(2) = 0.93 and 0.88; change: R(2) = 0.82 and 0.87, respectively), while lower for the global method (baseline: R(2) = 0.79; change: R(2) = 0.54). The SDC-HOS were 9.8-18.6% and 5.9-10.7% for the semiaxial and semicoronal methods, respectively.CONCLUSION: Detection of SIJ BME in the semiaxial scan plane is feasible and reproducible. However, a slightly lower reliability of all 3 semiaxial methods supports the general practice of using the coronal scan-plane in therapeutic studies.

KW - Journal Article

U2 - 10.3899/jrheum.161583

DO - 10.3899/jrheum.161583

M3 - Journal article

C2 - 28966208

VL - 45

SP - 70

EP - 77

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 1

ER -