Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE

A. G. Kristensen, H. Bostock, N. B. Finnerup, H. Andersen, T. S. Jensen, S. Gylfadottir, M. Itani, T. Krøigård, S. Sindrup, H. Tankisi*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: Detection of motor involvement in diabetic polyneuropathy (DPN) by nerve conduction studies (NCS) does not occur until there is substantial loss of motor units, because collateral reinnervation maintains compound muscle action potential (CMAP) amplitude. Motor unit number estimation (MUNE) methods may therefore be more sensitive. This study was undertaken to test whether the novel method, MScanFit MUNE (MScan) can detect motor involvement in DPN despite normal NCS. Methods: Fifty-two type-2 diabetic patients and 38 healthy controls were included. The median nerve was examined in all participants using standard NCS and a detailed CMAP scan, used for MScan. Additional lower extremity NCS in patients were used for DPN diagnosis. Results: Of 52 diabetic patients, 21 had NCS-defined DPN while lower extremity NCS were normal in 31 patients. MScan motor unit number and size showed higher sensitivity and incidence of abnormality than motor NCS parameters, and a similar sensitivity to sensory NCS. Conclusions: MScan is able to detect motor axonal damage at times when collateral reinnervation limits NCS changes. Significance: MScan is a sensitive method to detect motor involvement in DPN, which our data suggests is present as early as sensory.

Original languageEnglish
JournalClinical Neurophysiology
Volume130
Issue number10
Pages (from-to)1981-1987
ISSN1388-2457
DOIs
Publication statusPublished - 1. Oct 2019

Fingerprint

Diabetic Neuropathies
Action Potentials
Muscles
Median Nerve
Incidence

Keywords

  • CMAP amplitude
  • Diabetic polyneuropathy
  • DPN
  • Motor involvement
  • Mscan
  • MScanFit MUNE
  • Nerve conduction studies

Cite this

Kristensen, A. G., Bostock, H., Finnerup, N. B., Andersen, H., Jensen, T. S., Gylfadottir, S., ... Tankisi, H. (2019). Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE. Clinical Neurophysiology, 130(10), 1981-1987. https://doi.org/10.1016/j.clinph.2019.08.003
Kristensen, A. G. ; Bostock, H. ; Finnerup, N. B. ; Andersen, H. ; Jensen, T. S. ; Gylfadottir, S. ; Itani, M. ; Krøigård, T. ; Sindrup, S. ; Tankisi, H. / Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE. In: Clinical Neurophysiology. 2019 ; Vol. 130, No. 10. pp. 1981-1987.
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abstract = "Objective: Detection of motor involvement in diabetic polyneuropathy (DPN) by nerve conduction studies (NCS) does not occur until there is substantial loss of motor units, because collateral reinnervation maintains compound muscle action potential (CMAP) amplitude. Motor unit number estimation (MUNE) methods may therefore be more sensitive. This study was undertaken to test whether the novel method, MScanFit MUNE (MScan) can detect motor involvement in DPN despite normal NCS. Methods: Fifty-two type-2 diabetic patients and 38 healthy controls were included. The median nerve was examined in all participants using standard NCS and a detailed CMAP scan, used for MScan. Additional lower extremity NCS in patients were used for DPN diagnosis. Results: Of 52 diabetic patients, 21 had NCS-defined DPN while lower extremity NCS were normal in 31 patients. MScan motor unit number and size showed higher sensitivity and incidence of abnormality than motor NCS parameters, and a similar sensitivity to sensory NCS. Conclusions: MScan is able to detect motor axonal damage at times when collateral reinnervation limits NCS changes. Significance: MScan is a sensitive method to detect motor involvement in DPN, which our data suggests is present as early as sensory.",
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Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE. / Kristensen, A. G.; Bostock, H.; Finnerup, N. B.; Andersen, H.; Jensen, T. S.; Gylfadottir, S.; Itani, M.; Krøigård, T.; Sindrup, S.; Tankisi, H.

In: Clinical Neurophysiology, Vol. 130, No. 10, 01.10.2019, p. 1981-1987.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE

AU - Kristensen, A. G.

AU - Bostock, H.

AU - Finnerup, N. B.

AU - Andersen, H.

AU - Jensen, T. S.

AU - Gylfadottir, S.

AU - Itani, M.

AU - Krøigård, T.

AU - Sindrup, S.

AU - Tankisi, H.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objective: Detection of motor involvement in diabetic polyneuropathy (DPN) by nerve conduction studies (NCS) does not occur until there is substantial loss of motor units, because collateral reinnervation maintains compound muscle action potential (CMAP) amplitude. Motor unit number estimation (MUNE) methods may therefore be more sensitive. This study was undertaken to test whether the novel method, MScanFit MUNE (MScan) can detect motor involvement in DPN despite normal NCS. Methods: Fifty-two type-2 diabetic patients and 38 healthy controls were included. The median nerve was examined in all participants using standard NCS and a detailed CMAP scan, used for MScan. Additional lower extremity NCS in patients were used for DPN diagnosis. Results: Of 52 diabetic patients, 21 had NCS-defined DPN while lower extremity NCS were normal in 31 patients. MScan motor unit number and size showed higher sensitivity and incidence of abnormality than motor NCS parameters, and a similar sensitivity to sensory NCS. Conclusions: MScan is able to detect motor axonal damage at times when collateral reinnervation limits NCS changes. Significance: MScan is a sensitive method to detect motor involvement in DPN, which our data suggests is present as early as sensory.

AB - Objective: Detection of motor involvement in diabetic polyneuropathy (DPN) by nerve conduction studies (NCS) does not occur until there is substantial loss of motor units, because collateral reinnervation maintains compound muscle action potential (CMAP) amplitude. Motor unit number estimation (MUNE) methods may therefore be more sensitive. This study was undertaken to test whether the novel method, MScanFit MUNE (MScan) can detect motor involvement in DPN despite normal NCS. Methods: Fifty-two type-2 diabetic patients and 38 healthy controls were included. The median nerve was examined in all participants using standard NCS and a detailed CMAP scan, used for MScan. Additional lower extremity NCS in patients were used for DPN diagnosis. Results: Of 52 diabetic patients, 21 had NCS-defined DPN while lower extremity NCS were normal in 31 patients. MScan motor unit number and size showed higher sensitivity and incidence of abnormality than motor NCS parameters, and a similar sensitivity to sensory NCS. Conclusions: MScan is able to detect motor axonal damage at times when collateral reinnervation limits NCS changes. Significance: MScan is a sensitive method to detect motor involvement in DPN, which our data suggests is present as early as sensory.

KW - CMAP amplitude

KW - Diabetic polyneuropathy

KW - DPN

KW - Motor involvement

KW - Mscan

KW - MScanFit MUNE

KW - Nerve conduction studies

U2 - 10.1016/j.clinph.2019.08.003

DO - 10.1016/j.clinph.2019.08.003

M3 - Journal article

C2 - 31476704

AN - SCOPUS:85071474814

VL - 130

SP - 1981

EP - 1987

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 10

ER -

Kristensen AG, Bostock H, Finnerup NB, Andersen H, Jensen TS, Gylfadottir S et al. Detection of early motor involvement in diabetic polyneuropathy using a novel MUNE method – MScanFit MUNE. Clinical Neurophysiology. 2019 Oct 1;130(10):1981-1987. https://doi.org/10.1016/j.clinph.2019.08.003