Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model

Marie Frederiksen, Katrin Vorkamp, Niels Martin Jensen, Jens Ahm Sørensen, Lisbeth E. Knudsen, Lars S Sørensen, Thomas F Webster, Jesper B Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, β and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.

Original languageEnglish
JournalChemosphere
Volume162
Pages (from-to)308-314
ISSN0045-6535
DOIs
Publication statusPublished - 1. Nov 2016

Keywords

  • Administration, Cutaneous
  • Adult
  • Environmental Monitoring
  • Female
  • Flame Retardants
  • Humans
  • Hydrocarbons, Brominated
  • Models, Biological
  • Organ Culture Techniques
  • Permeability
  • Skin
  • Skin Absorption
  • Journal Article
  • NBFR
  • Dermal exposure
  • Skin deposition
  • Brominated flame retardants
  • Dechlorane plus
  • HBCDD

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