TY - JOUR
T1 - Demographic and clinical features of neuromyelitis optica
T2 - A review
AU - Pandit, L.
AU - Asgari, Nasrin
AU - Apiwattanakul, M.
AU - Palace, J.
AU - Paul, F.
AU - Leite, M. I.
AU - Kleiter, I.
AU - Chitnis, T.
N1 - 3 25921037
PY - 2015
Y1 - 2015
N2 - The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.
AB - The comparative clinical and demographic features of neuromyelitis optica (NMO) are not well known. In this review we analyzed peer-reviewed publications for incidence and prevalence, clinical phenotypes, and demographic features of NMO. Population-based studies from Europe, South East and Southern Asia, the Caribbean, and Cuba suggest that the incidence and prevalence of NMO ranges from 0.05-0.4 and 0.52-4.4 per 100,000, respectively. Mean age at onset (32.6-45.7) and median time to first relapse (8-12 months) was similar. Most studies reported an excess of disease in women and a relapsing course, particularly in anti-aquaporin 4 antibody (anti AQP4-IgG)-positive patients. Ethnicity may have a bearing on disease phenotype and clinical outcome. Despite limitations inherent to the review process, themes noted in clinical and demographic features of NMO among different populations promote a more global understanding of NMO and strategies to address it.
KW - NMO epidemiology demographics incidence prevalence EXTENSIVE TRANSVERSE MYELITIS MULTIPLE-SCLEROSIS PROGNOSTIC-FACTORS AQUAPORIN-4 AUTOIMMUNITY UNITED-KINGDOM MULTICENTER POPULATION SPECTRUM NMO DISORDERS
U2 - 10.1177/1352458515572406
DO - 10.1177/1352458515572406
M3 - Journal article
C2 - 25921037
SN - 1352-4585
VL - 21
SP - 845
EP - 853
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 7
ER -