Abstract
The most significant risk factor for cardiovascular disease is, sadly, aging, which is an unavoidable aspect of life. There are still many open concerns regarding how the genetic processes governing aging in model species affect cardiovascular aging, even though countless studies in the cardiovascular area have taken into account both young and old humans. Similar to this, there isn’t much research that comprehensively evaluates how these longevity pathways affect cardiovascular health in the field of the molecular biology of aging. Thankfully, this chasm is starting to close, and these two fields are combining. We present an overview of some of the central genes involved in regulating longevity pathways, including insulin-like growth factor 1, AMP-activated protein kinase, forkhead transcription factors, sirtuins, and mammalian target of rapamycin, as well as their implications in cardiovascular health. In addition, we provide insight into network medicine-based approaches to identify additional genes connected with longevity genes within an interactome space that are involved in regulating the age-related cardiovascular signaling axes. In this context, we addressed many in vitro, in vivo, and human clinical trial studies to better appreciate how essential phytochemicals can be in the fight against age-related cardiovascular disorders.
| Original language | English |
|---|---|
| Title of host publication | Evidence-based Functional Foods for Prevention of Age-related Diseases |
| Editors | Surajit Pathak, Antara Banerjee, Asim K Duttaroy |
| Publisher | Springer |
| Publication date | 1. Jan 2023 |
| Pages | 245-262 |
| Chapter | 13 |
| ISBN (Print) | 978-981-99-0533-1 |
| ISBN (Electronic) | 978-981-99-0534-8 |
| DOIs | |
| Publication status | Published - 1. Jan 2023 |
Keywords
- Aging
- Cardiovascular disease
- Longevity genes
- Network medicine
- Phytochemicals
- Network medicine Phytochemicals