Decorin is down-regulated in multiple myeloma and MGUS bone marrow plasma and inhibits HGF-induced myeloma plasma cell viability and migration

Ida Bruun Kristensen, Lise Mariager Pedersen, Torstein Baade Rø, Jacob Haaber Christensen, Maria Bibi Lyng, Lars Melholt Rasmussen, Henrik J Ditzel, Magne Børset, Niels Abildgaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVES: Decorin is a stromal-produced small leucine-rich proteoglycan known to attenuate tumour pro-survival, migration, proliferation and angiogenic signalling pathways. Recent studies have shown that decorin interacts with the hepatocyte growth factor (HGF) receptor c-Met, a potential key pathway in multiple myeloma (MM). METHODS: Decorin levels in paired peripheral blood and bone marrow plasma samples from healthy volunteers (HV) (n=23), and patients with monoclonal gammopathy of undetermined significance (MGUS) (n=41) and MM (n=19) were determined by ELISA. Further, the ability of decorin to inhibit HGF-induced effects on MM cell lines were analysed in vitro using cell viability and Transwell migration assays. RESULTS: We found that decorin concentrations were significantly higher (p
Original languageEnglish
JournalEuropean Journal of Haematology
Volume91
Issue number3
Pages (from-to)196–200
Number of pages5
ISSN0902-4441
DOIs
Publication statusPublished - Sept 2013

Keywords

  • Aged
  • Aged, 80 and over
  • Bone Marrow Cells/drug effects
  • Cell Line, Tumor
  • Cell Movement/drug effects
  • Cell Survival/drug effects
  • Decorin/metabolism
  • Down-Regulation
  • Female
  • Hepatocyte Growth Factor/pharmacology
  • Humans
  • Male
  • Middle Aged
  • Monoclonal Gammopathy of Undetermined Significance/metabolism
  • Multiple Myeloma/metabolism
  • Plasma Cells/drug effects
  • Proto-Oncogene Proteins c-met/metabolism

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