Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study

J. Bousquet*, P. Devillier, J. M. Anto, M. Bewick, T. Haahtela, S. Arnavielhe, A. Bedbrook, R. Murray, M. van Eerd, J. A. Fonseca, M. Morais Almeida, A. Todo Bom, E. Menditto, G. Passalacqua, C. Stellato, M. Triggiani, M. T. Ventura, G. Vezzani, I. Annesi-Maesano, R. BourretI. Bosse, D. Caimmi, C. Cartier, P. Demoly, J. Just, F. Portejoie, V. Siroux, F. Viart, K. C. Bergmann, T. Keil, L. Klimek, R. Mösges, O. Pfaar, S. Shamai, T. Zuberbier, J. Mullol, A. Valero, O. Spranger, P. V. Tomazic, M. L. Kowalski, P. Kuna, M. Kupczyk, F. Raciborski, B. Samolinski, S. K. Toppila-Salmi, E. Valovirta, A. A. Cruz, C. Bindslev-Jensen, E. Eller, M. Sorensen

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

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Abstract

Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as "Low" burden and VAS levels ≥50/100 as "High" burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on "Low" and "High" VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High-Asthma Low pattern. There were 1.7% days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume73
Issue number8
Pages (from-to)1622-1631
ISSN0105-4538
DOIs
Publication statusPublished - Aug 2018

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Visual Analog Scale
Comorbidity
Conjunctivitis
Nose
Hypersensitivity
Prospective Studies

Bibliographical note

© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Keywords

  • Asthma
  • Conjunctivitis
  • Multimorbidity
  • Rhinitis
  • Work productivity

Cite this

Bousquet, J., Devillier, P., Anto, J. M., Bewick, M., Haahtela, T., Arnavielhe, S., ... Sorensen, M. (2018). Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study. Allergy: European Journal of Allergy and Clinical Immunology, 73(8), 1622-1631. https://doi.org/10.1111/all.13448
Bousquet, J. ; Devillier, P. ; Anto, J. M. ; Bewick, M. ; Haahtela, T. ; Arnavielhe, S. ; Bedbrook, A. ; Murray, R. ; van Eerd, M. ; Fonseca, J. A. ; Morais Almeida, M. ; Todo Bom, A. ; Menditto, E. ; Passalacqua, G. ; Stellato, C. ; Triggiani, M. ; Ventura, M. T. ; Vezzani, G. ; Annesi-Maesano, I. ; Bourret, R. ; Bosse, I. ; Caimmi, D. ; Cartier, C. ; Demoly, P. ; Just, J. ; Portejoie, F. ; Siroux, V. ; Viart, F. ; Bergmann, K. C. ; Keil, T. ; Klimek, L. ; Mösges, R. ; Pfaar, O. ; Shamai, S. ; Zuberbier, T. ; Mullol, J. ; Valero, A. ; Spranger, O. ; Tomazic, P. V. ; Kowalski, M. L. ; Kuna, P. ; Kupczyk, M. ; Raciborski, F. ; Samolinski, B. ; Toppila-Salmi, S. K. ; Valovirta, E. ; Cruz, A. A. ; Bindslev-Jensen, C. ; Eller, E. ; Sorensen, M. / Daily allergic multimorbidity in rhinitis using mobile technology : A novel concept of the MASK study. In: Allergy: European Journal of Allergy and Clinical Immunology. 2018 ; Vol. 73, No. 8. pp. 1622-1631.
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abstract = "Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as {"}Low{"} burden and VAS levels ≥50/100 as {"}High{"} burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on {"}Low{"} and {"}High{"} VAS levels. There were <0.2{\%} days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9{\%} days with a Rhinitis High-Asthma Low pattern. There were 1.7{\%} days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9{\%} days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.",
keywords = "Asthma, Conjunctivitis, Multimorbidity, Rhinitis, Work productivity",
author = "J. Bousquet and P. Devillier and Anto, {J. M.} and M. Bewick and T. Haahtela and S. Arnavielhe and A. Bedbrook and R. Murray and {van Eerd}, M. and Fonseca, {J. A.} and {Morais Almeida}, M. and {Todo Bom}, A. and E. Menditto and G. Passalacqua and C. Stellato and M. Triggiani and Ventura, {M. T.} and G. Vezzani and I. Annesi-Maesano and R. Bourret and I. Bosse and D. Caimmi and C. Cartier and P. Demoly and J. Just and F. Portejoie and V. Siroux and F. Viart and Bergmann, {K. C.} and T. Keil and L. Klimek and R. M{\"o}sges and O. Pfaar and S. Shamai and T. Zuberbier and J. Mullol and A. Valero and O. Spranger and Tomazic, {P. V.} and Kowalski, {M. L.} and P. Kuna and M. Kupczyk and F. Raciborski and B. Samolinski and Toppila-Salmi, {S. K.} and E. Valovirta and Cruz, {A. A.} and C. Bindslev-Jensen and E. Eller and M. Sorensen",
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year = "2018",
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language = "English",
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journal = "Allergy: European Journal of Allergy and Clinical Immunology",
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Bousquet, J, Devillier, P, Anto, JM, Bewick, M, Haahtela, T, Arnavielhe, S, Bedbrook, A, Murray, R, van Eerd, M, Fonseca, JA, Morais Almeida, M, Todo Bom, A, Menditto, E, Passalacqua, G, Stellato, C, Triggiani, M, Ventura, MT, Vezzani, G, Annesi-Maesano, I, Bourret, R, Bosse, I, Caimmi, D, Cartier, C, Demoly, P, Just, J, Portejoie, F, Siroux, V, Viart, F, Bergmann, KC, Keil, T, Klimek, L, Mösges, R, Pfaar, O, Shamai, S, Zuberbier, T, Mullol, J, Valero, A, Spranger, O, Tomazic, PV, Kowalski, ML, Kuna, P, Kupczyk, M, Raciborski, F, Samolinski, B, Toppila-Salmi, SK, Valovirta, E, Cruz, AA, Bindslev-Jensen, C, Eller, E & Sorensen, M 2018, 'Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study', Allergy: European Journal of Allergy and Clinical Immunology, vol. 73, no. 8, pp. 1622-1631. https://doi.org/10.1111/all.13448

Daily allergic multimorbidity in rhinitis using mobile technology : A novel concept of the MASK study. / Bousquet, J.; Devillier, P.; Anto, J. M.; Bewick, M.; Haahtela, T.; Arnavielhe, S.; Bedbrook, A.; Murray, R.; van Eerd, M.; Fonseca, J. A.; Morais Almeida, M.; Todo Bom, A.; Menditto, E.; Passalacqua, G.; Stellato, C.; Triggiani, M.; Ventura, M. T.; Vezzani, G.; Annesi-Maesano, I.; Bourret, R.; Bosse, I.; Caimmi, D.; Cartier, C.; Demoly, P.; Just, J.; Portejoie, F.; Siroux, V.; Viart, F.; Bergmann, K. C.; Keil, T.; Klimek, L.; Mösges, R.; Pfaar, O.; Shamai, S.; Zuberbier, T.; Mullol, J.; Valero, A.; Spranger, O.; Tomazic, P. V.; Kowalski, M. L.; Kuna, P.; Kupczyk, M.; Raciborski, F.; Samolinski, B.; Toppila-Salmi, S. K.; Valovirta, E.; Cruz, A. A.; Bindslev-Jensen, C.; Eller, E.; Sorensen, M.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 73, No. 8, 08.2018, p. 1622-1631.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Daily allergic multimorbidity in rhinitis using mobile technology

T2 - A novel concept of the MASK study

AU - Bousquet, J.

AU - Devillier, P.

AU - Anto, J. M.

AU - Bewick, M.

AU - Haahtela, T.

AU - Arnavielhe, S.

AU - Bedbrook, A.

AU - Murray, R.

AU - van Eerd, M.

AU - Fonseca, J. A.

AU - Morais Almeida, M.

AU - Todo Bom, A.

AU - Menditto, E.

AU - Passalacqua, G.

AU - Stellato, C.

AU - Triggiani, M.

AU - Ventura, M. T.

AU - Vezzani, G.

AU - Annesi-Maesano, I.

AU - Bourret, R.

AU - Bosse, I.

AU - Caimmi, D.

AU - Cartier, C.

AU - Demoly, P.

AU - Just, J.

AU - Portejoie, F.

AU - Siroux, V.

AU - Viart, F.

AU - Bergmann, K. C.

AU - Keil, T.

AU - Klimek, L.

AU - Mösges, R.

AU - Pfaar, O.

AU - Shamai, S.

AU - Zuberbier, T.

AU - Mullol, J.

AU - Valero, A.

AU - Spranger, O.

AU - Tomazic, P. V.

AU - Kowalski, M. L.

AU - Kuna, P.

AU - Kupczyk, M.

AU - Raciborski, F.

AU - Samolinski, B.

AU - Toppila-Salmi, S. K.

AU - Valovirta, E.

AU - Cruz, A. A.

AU - Bindslev-Jensen, C.

AU - Eller, E.

AU - Sorensen, M.

N1 - © 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

PY - 2018/8

Y1 - 2018/8

N2 - Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as "Low" burden and VAS levels ≥50/100 as "High" burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on "Low" and "High" VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High-Asthma Low pattern. There were 1.7% days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

AB - Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as "Low" burden and VAS levels ≥50/100 as "High" burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on "Low" and "High" VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High-Asthma Low pattern. There were 1.7% days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

KW - Asthma

KW - Conjunctivitis

KW - Multimorbidity

KW - Rhinitis

KW - Work productivity

U2 - 10.1111/all.13448

DO - 10.1111/all.13448

M3 - Review

C2 - 29569295

AN - SCOPUS:85045929487

VL - 73

SP - 1622

EP - 1631

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 8

ER -