Cytogenetic investigation in twins with manic-depressive disorders (22 monozygotic and 27 dizygotic twin pairs)

J Nielsen, A Homma, A Bertelsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Chromosome examination was made in 22 monozygotic and 27 dizygotic twin pairs of whom one or both of each pair suffered or had suffered from manic-depressive disorder. We found a significantly higher frequency of chromosome variations among dizygotic twin pairs than was expected from population studies, but not in monozygotic pairs. There was no association between the chromosome variations and manic-depressive disorders. We found no greater intra-pair correlation in monozygotic twins compared with dizygotic twins as regards hypodiploidy, hyperdiploidy and unstable chromosome aberrations, which indicates that the aetiology of such aberrations is mainly of exogenic nature.

Original languageEnglish
JournalBritish Journal of Psychiatry
Volume130
Pages (from-to)352-4
Number of pages3
ISSN0007-1250
DOIs
Publication statusPublished - Apr 1977

Keywords

  • Bipolar Disorder/genetics
  • Chromosome Aberrations
  • Female
  • Humans
  • Male
  • Pregnancy
  • Twins
  • Twins, Dizygotic
  • Twins, Monozygotic

Fingerprint

Dive into the research topics of 'Cytogenetic investigation in twins with manic-depressive disorders (22 monozygotic and 27 dizygotic twin pairs)'. Together they form a unique fingerprint.

Cite this