CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients

Martin H Pedersen, Brian L Hood, Sidse Ehmsen, Hans C Beck, Thomas P Conrads, Martin Bak, Henrik J Ditzel, Rikke Leth-Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

171 Downloads (Pure)

Abstract

Prognostic and predictive biomarkers of disease and treatment outcome are needed to ensure optimal treatment of patients with triple-negative breast cancer (TNBC). In a mass spectrometry-based global proteomic study of 44 formalin-fixed, paraffin-embedded (FFPE) primary TNBC tumors and 10 corresponding metastases, we found that Cytochrome P450 reductase (CYPOR) expression correlated with patient outcome. The correlation between CYPOR expression and outcome was further evaluated in a Danish cohort of 113 TNBC patients using immunohistochemistry and publicly available gene expression data from two cohorts of TNBC and basal-like breast cancer patients, respectively (N = 249 and N = 580). A significant correlation between high CYPOR gene expression and shorter recurrence-free survival (RFS), but not overall survival, was found in the cohort of 249 TNBC patients (p = 0.018, HR = 1.77, 95% CI 1.1–2.85), and this correlation was recapitulated in a cohort of 580 basal-like breast cancer patients (p = 0.018, HR = 1.4, 95% CI 1.06–1.86). High CYPOR protein expression was also associated with shorter RFS in the cohort of 113 TNBC patients (p = 0.017, HR = 2.73, 95% CI 1.20–6.19), particularly those who were lymph node tumor-negative (p = 0.029, HR = 5.22). Multivariate Cox regression analysis identified CYPOR as an independent prognostic factor for shorter RFS in TNBC patients (p = 0.032, HR = 2.19, 95% CI 1.07–4.47). Together, these data suggest high expression of CYPOR as an independent prognostic biomarker of shorter RFS, which could be used to identify patients who should receive more extensive adjuvant treatment and more aggressive surveillance.

Original languageEnglish
JournalInternational Journal of Cancer
Volume144
Issue number3
Pages (from-to)631-640
ISSN0020-7136
DOIs
Publication statusPublished - 1. Feb 2019

Keywords

  • CYPOR
  • biomarker
  • formalin-fixed paraffin-embedded
  • mass spectrometry
  • triple-negative breast cancer

Fingerprint Dive into the research topics of 'CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients'. Together they form a unique fingerprint.

Cite this