CPAnet Registry-An International Chronic Pulmonary Aspergillosis Registry

Christian B Laursen, Jesper Rømhild Davidsen, Lander Van Acker, Helmut J F Salzer, Danila Seidel, Oliver A Cornely, Martin Hoenigl, Ana Alastruey-Izquierdo, Christophe Hennequin, Cendrine Godet, Aleksandra Barac, Holger Flick, Oxana Munteanu, Eva Van Braeckel

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Abstract

Chronic pulmonary aspergillosis (CPA) is a chronic fungal infection of the lung associated with high morbidity and mortality. The CPA Research network (CPAnet) registry established in 2018 is an international multicenter collaboration aiming to improve CPA knowledge and patient care. This study's aim was to describe the data collection process and content of CPAnet registry with preliminary clinical data. In the CPAnet registry, clinical data are collected through a web-based questionnaire. Data include CPA phenotype, comorbidities, treatment, outcome, and follow-up from several international centers. An exemplary descriptive analysis was performed on 74 patients, who were registered online before April 2020. CPA patients were predominantly (72%) male, 39% had chronic obstructive pulmonary disease, and 68% had a history of smoking. Chronic cavitary pulmonary aspergillosis was the most common CPA subtype (62%). In 32 patients (52%), voriconazole was the preferred first-line therapy. The multicenter multinational CPAnet registry is a valuable approach to gather comprehensive data on a large study population and reflects real-world clinical practice rather than focusing on specific patient populations in more specialized centers. Additional CPA reference centers are being encouraged to join this promising clinical research collaboration.

Original languageEnglish
Article number96
JournalJournal of Fungi
Volume6
Issue number3
Number of pages14
ISSN2309-608X
DOIs
Publication statusPublished - 29. Jun 2020

Keywords

  • Antifungals
  • Aspergillus
  • CPAnet
  • Chronic pulmonary aspergillosis
  • Diagnosis
  • International collaboration
  • Registry
  • Treatment

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    Laursen, C. B., Davidsen, J. R., Van Acker, L., Salzer, H. J. F., Seidel, D., Cornely, O. A., Hoenigl, M., Alastruey-Izquierdo, A., Hennequin, C., Godet, C., Barac, A., Flick, H., Munteanu, O., & Van Braeckel, E. (2020). CPAnet Registry-An International Chronic Pulmonary Aspergillosis Registry. Journal of Fungi, 6(3), [96]. https://doi.org/10.3390/jof6030096