TY - JOUR
T1 - Counteracting age-related loss of skeletal muscle mass
T2 - a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial
AU - Bechshøft, Rasmus
AU - Reitelseder, Søren
AU - Højfeldt, Grith Stougaard
AU - Castro Mejia, Josue Leonardo
AU - Khakimov, Bekzod
AU - Bin Ahmad, Hajar Fauzan
AU - Kjær, Michael
AU - Engelsen, Søren Balling
AU - Laugesen, Susanne Margrete Bølling
AU - Rasmussen, Morten Arendt
AU - Lassen, Aske Juul
AU - Jensen, Tenna
AU - Beyer, Nina
AU - Serena, Anja
AU - Perez-Cueto, Armando
AU - Nielsen, Dennis Sandris
AU - Jespersen, Astrid Pernille
AU - Holm, Lars
PY - 2016/8/9
Y1 - 2016/8/9
N2 - BACKGROUND: Aging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.METHODS: We will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DISCUSSION: The primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.TRIAL REGISTRATION: ClinicalTrials.gov NCT02034760 . Registered on 10 January 2014. ClinicalTrials.gov NCT02115698 . Registered on 14 April 2014. Danish regional committee of the Capital Region H-4-2013-070. Registered on 4 July 2013. Danish Data Protection Agency 2012-58-0004 - BBH-2015-001 I-Suite 03432. Registered on 9 January 2015.
AB - BACKGROUND: Aging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.METHODS: We will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DISCUSSION: The primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.TRIAL REGISTRATION: ClinicalTrials.gov NCT02034760 . Registered on 10 January 2014. ClinicalTrials.gov NCT02115698 . Registered on 14 April 2014. Danish regional committee of the Capital Region H-4-2013-070. Registered on 4 July 2013. Danish Data Protection Agency 2012-58-0004 - BBH-2015-001 I-Suite 03432. Registered on 9 January 2015.
KW - Elderly
KW - Gut microbiome
KW - Muscle
KW - Plasma metabolome
KW - Protein
KW - Strength training
KW - Whey
KW - Body Composition
KW - Single-Blind Method
KW - Double-Blind Method
KW - Humans
KW - Clinical Protocols
KW - Gastrointestinal Microbiome
KW - Metabolome
KW - Ethnology
KW - Feeding Behavior
KW - Resistance Training
KW - Sarcopenia/prevention & control
KW - Dietary Proteins/administration & dosage
KW - Dietary Supplements
U2 - 10.1186/s13063-016-1512-0
DO - 10.1186/s13063-016-1512-0
M3 - Journal article
C2 - 27507236
SN - 1745-6215
VL - 17
JO - Trials
JF - Trials
IS - 1
M1 - 397
ER -