Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Morten T Venø, Susanne T Venø, Kati Rehberg, Jessy V. van Asperen, Bettina H. Clausen, Ida E Holm, R. Jeroen Pasterkamp, Bente Finsen, Jørgen Kjems

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Abstract

The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.

Original languageEnglish
Article number31
JournalFrontiers in Molecular Neuroscience
Volume10
Number of pages10
ISSN1662-5099
DOIs
Publication statusPublished - 2017

Keywords

  • Brain development
  • Cortical morphogenesis
  • Embryonic development
  • microRNA
  • miR-204
  • miR-34c
  • Neuronal migration

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