Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Morten T Venø; Susanne T Venø; Kati Rehberg; Jessy V. van Asperen; Bettina H. Clausen; Ida E Holm; R. Jeroen Pasterkamp; Bente Finsen; Jørgen Kjems

doi:10.3389/fnmol.2017.00031

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Morten T Venø, Susanne T Venø, Kati Rehberg, Jessy V. van Asperen, Bettina H. Clausen, Ida E Holm, R. Jeroen Pasterkamp, Bente Finsen, Jørgen Kjems

KI, BRIDGE - Brain Research - Inter Disciplinary Guided Excellence (Odense)

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.

Original language	English
Article number	31
Journal	Frontiers in Molecular Neuroscience
Volume	10
Number of pages	10
ISSN	1662-5099
DOIs	https://doi.org/10.3389/fnmol.2017.00031
Publication status	Published - 2017

Keywords

Brain development
Cortical morphogenesis
Embryonic development
microRNA
miR-204
miR-34c
Neuronal migration

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10.3389/fnmol.2017.00031Licence: CC BY

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204Final published version, 3.12 MBLicence: CC BY

Cite this

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title = "Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204",

abstract = "The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.",

keywords = "Brain development, Cortical morphogenesis, Embryonic development, microRNA, miR-204, miR-34c, Neuronal migration",

author = "Ven{\o}, {Morten T} and Ven{\o}, {Susanne T} and Kati Rehberg and {van Asperen}, {Jessy V.} and Clausen, {Bettina H.} and Holm, {Ida E} and Pasterkamp, {R. Jeroen} and Bente Finsen and J{\o}rgen Kjems",

year = "2017",

doi = "10.3389/fnmol.2017.00031",

language = "English",

volume = "10",

journal = "Frontiers in Molecular Neuroscience",

issn = "1662-5099",

publisher = "Frontiers Research Foundation",

}

TY - JOUR

T1 - Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

AU - Venø, Morten T

AU - Venø, Susanne T

AU - Rehberg, Kati

AU - van Asperen, Jessy V.

AU - Clausen, Bettina H.

AU - Holm, Ida E

AU - Pasterkamp, R. Jeroen

AU - Finsen, Bente

AU - Kjems, Jørgen

PY - 2017

Y1 - 2017

N2 - The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.

AB - The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.

KW - Brain development

KW - Cortical morphogenesis

KW - Embryonic development

KW - microRNA

KW - miR-204

KW - miR-34c

KW - Neuronal migration

U2 - 10.3389/fnmol.2017.00031

DO - 10.3389/fnmol.2017.00031

M3 - Journal article

C2 - 28232790

AN - SCOPUS:85014030906

SN - 1662-5099

VL - 10

JO - Frontiers in Molecular Neuroscience

JF - Frontiers in Molecular Neuroscience

M1 - 31

ER -

Cortical morphogenesis during embryonic development is regulated by miR-34c and miR-204

Abstract

Keywords

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