TY - JOUR
T1 - Correction to
T2 - Higher bone mineral density at six years of age in very preterm-born infants fed human milk compared to formula feeding. A secondary analysis of an RCT (European Journal of Pediatrics, (2025), 184, 2, (160), 10.1007/s00431-024-05935-3)
AU - Toftlund, Line H.
AU - Beck-Nielsen, Signe Sparre
AU - Agertoft, Lone
AU - Halken, Susanne
AU - Zachariassen, Gitte
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/3
Y1 - 2025/3
N2 - In the originally published article entitled “Higher bone mineral density at six years of age in very preterm-born infants fed human milk compared to formula feeding. A secondary analysis of an RCT”, Table 1 is very unregular and is difficult to read, unfortunately. Table 1 Baseline characteristics (Table presented.) UHM FHM (UHM + FHM) HM PF (FHM + PF) Protein UHM vs FHM t-test p-value HM vs PF t-test p-value UHM vs Pro t-test p-value 59 67 126 66 133 11 13 24 17 30 0.35 1.00 0.70 29 30 59 41 71 0.05* 0.72 0.64 12 28 40 30 58 0.08 0.01* 0.002* Median 204 204 213 209 207 212 Min 169 171 169 184 171 Max 224 224 224 222 224 Birth weight (g) Median 1221 1330 1265 1282 1294 Min 548 690 548 612 612 Max 2255 2024 2255 2140 2140 Age at discharge (days) Median 262 261 262 257 259 Min 243 243 243 245 243 Max 319 297 319 286 297 Age at DXA (years) Median 6.3 6.3 6.3 6.2 6.3 Min 5.8 5.8 5.8 5.8 5.8 Max 8.3 7.7 8.3 7.2 7.7 Weight at DXA (kg) Median 21.5 20.8 21.1 21.4 21.0 Min 16.0 13.9 13.9 16.8 13.9 Max 35.1 33.8 35.1 40.0 40.0 Weight growth (Z-score dif. from GA 34 to 2 months CA) Mean 0.79 0.96 0.88 1.31 1.13 0.28 0.002* 0.01* SD 0.87 0.88 0.87 0.91 0.91 Mean − 0.16 − 0.40 − 0.29 − 0.09 − 0.24 0.22 0.27 0.62 SD 1.06 1.14 1.10 1.24 1.20 Height at DXA (cm) Mean 120.61 119.56 120.05 118.97 119.27 0.28 0.18 0.12 SD 5.56 5.16 5.35 5.23 5.19 Mean 0.11 0.01 0.06 − 0.10 − 0.04 0.58 0.31 0.32 SD 0.99 1.10 1.04 1.00 1.05 Mean 9.75 9.71 9.73 9.73 9.72 0.10 0.79 0.12 SD 0.14 0.13 0.13 0.13 0.12 Mean 8.03 8.02 8.02 8.14 8.08 0.90 0.15 0.55 SD 0.53 0.52 0.52 0.57 0.54 GA gestational age, and BW birth weight, no significant difference comparing groups, SGA small for gestational age, CA corrected age, LBM lean body mass, FM fat mass, n numbers, UHM unfortified human milk, FHM fortified human milk, HM human milk (UHM + FHM), PF preterm formula, Pro protein (PF + FHM), dif difference Table 1 Baseline characteristics (Table presented.) UHM FHM (UHM + FHM) HM PF (FHM + PF) Protein UHM vs FHM t-test HM vs PF t-test UHM vs Pro. t-test Children DXA n 59 67 126 66 133 SGA at birth n 11 13 24 17 30 0.35 1.00 0.70 Boys n 29 30 59 41 71 0.05* 0.72 0.64 Multiple birth n 12 28 40 30 58 0.08 0.01* 0.002* GA Median 204.0 213.0 209.5 207.0 212.0 Min 169.0 171.0 169.0 184.0 171.0 Max 224.0 224.0 224.0 222.0 224.0 Birth weight (g) Median 1221.0 1330.0 1264.5 1282.5 1294.0 Min 548.0 690.0 548.0 612.0 612.0 Max 2255.0 2024.0 2255.0 2140.0 2140.0 Age at discharge (days) Median 262.0 261.0 261.5 257.0 259.0 Min 243.0 243.0 243.0 245.0 243.0 Max 319.0 297.0 319.0 286.0 297.0 Age at DXA (years) Median 6.3 6.3 6.3 6.2 6.3 Min 5.8 5.8 5.8 5.8 5.8 Max 8.3 7.7 8.3 7.2 7.7 Weight at DXA (kg) Median 21.5 20.8 21.1 21.4 21.0 Min 16.0 13.9 13.9 16.8 13.9 Max 35.1 33.8 35.1 40.0 40.0 Weight growth (Z-score dif. from GA 34 to 2 months CA) Mean 0.79 0.96 0.88 1.31 1.13 0.28 0.002* 0.01* SD 0.87 0.88 0.87 0.91 0.91 Weight z-score DXA Mean −0.16 −0.40 −0.29 −0.09 −0.24 0.22 0.27 0.62 SD 1.06 1.14 1.10 1.24 1.20 Height at DXA (cm) Mean 120.61 119.56 120.05 118.97 119.27 0.28 0.18 0.12 SD 5.56 5.16 5.35 5.23 5.19 Height z-score DXA Mean 0.11 0.01 0.06 −0.10 −0.04 0.58 0.31 0.32 SD 0.99 1.10 1.04 1.00 1.05 LBM Mean 9.75 9.71 9.73 9.73 9.72 0.10 0.79 0.12 SD 0.14 0.13 0.13 0.13 0.12 FM Mean 8.03 8.02 8.02 8.14 8.08 0.90 0.15 0.55 SD 0.53 0.52 0.52 0.57 0.54 GA = gestational age and BW = birth weight, no significant difference comparing groups. CA = corrected age, LBM = lean body mass, FM = fat mass, n = numbers The original article has been corrected.
AB - In the originally published article entitled “Higher bone mineral density at six years of age in very preterm-born infants fed human milk compared to formula feeding. A secondary analysis of an RCT”, Table 1 is very unregular and is difficult to read, unfortunately. Table 1 Baseline characteristics (Table presented.) UHM FHM (UHM + FHM) HM PF (FHM + PF) Protein UHM vs FHM t-test p-value HM vs PF t-test p-value UHM vs Pro t-test p-value 59 67 126 66 133 11 13 24 17 30 0.35 1.00 0.70 29 30 59 41 71 0.05* 0.72 0.64 12 28 40 30 58 0.08 0.01* 0.002* Median 204 204 213 209 207 212 Min 169 171 169 184 171 Max 224 224 224 222 224 Birth weight (g) Median 1221 1330 1265 1282 1294 Min 548 690 548 612 612 Max 2255 2024 2255 2140 2140 Age at discharge (days) Median 262 261 262 257 259 Min 243 243 243 245 243 Max 319 297 319 286 297 Age at DXA (years) Median 6.3 6.3 6.3 6.2 6.3 Min 5.8 5.8 5.8 5.8 5.8 Max 8.3 7.7 8.3 7.2 7.7 Weight at DXA (kg) Median 21.5 20.8 21.1 21.4 21.0 Min 16.0 13.9 13.9 16.8 13.9 Max 35.1 33.8 35.1 40.0 40.0 Weight growth (Z-score dif. from GA 34 to 2 months CA) Mean 0.79 0.96 0.88 1.31 1.13 0.28 0.002* 0.01* SD 0.87 0.88 0.87 0.91 0.91 Mean − 0.16 − 0.40 − 0.29 − 0.09 − 0.24 0.22 0.27 0.62 SD 1.06 1.14 1.10 1.24 1.20 Height at DXA (cm) Mean 120.61 119.56 120.05 118.97 119.27 0.28 0.18 0.12 SD 5.56 5.16 5.35 5.23 5.19 Mean 0.11 0.01 0.06 − 0.10 − 0.04 0.58 0.31 0.32 SD 0.99 1.10 1.04 1.00 1.05 Mean 9.75 9.71 9.73 9.73 9.72 0.10 0.79 0.12 SD 0.14 0.13 0.13 0.13 0.12 Mean 8.03 8.02 8.02 8.14 8.08 0.90 0.15 0.55 SD 0.53 0.52 0.52 0.57 0.54 GA gestational age, and BW birth weight, no significant difference comparing groups, SGA small for gestational age, CA corrected age, LBM lean body mass, FM fat mass, n numbers, UHM unfortified human milk, FHM fortified human milk, HM human milk (UHM + FHM), PF preterm formula, Pro protein (PF + FHM), dif difference Table 1 Baseline characteristics (Table presented.) UHM FHM (UHM + FHM) HM PF (FHM + PF) Protein UHM vs FHM t-test HM vs PF t-test UHM vs Pro. t-test Children DXA n 59 67 126 66 133 SGA at birth n 11 13 24 17 30 0.35 1.00 0.70 Boys n 29 30 59 41 71 0.05* 0.72 0.64 Multiple birth n 12 28 40 30 58 0.08 0.01* 0.002* GA Median 204.0 213.0 209.5 207.0 212.0 Min 169.0 171.0 169.0 184.0 171.0 Max 224.0 224.0 224.0 222.0 224.0 Birth weight (g) Median 1221.0 1330.0 1264.5 1282.5 1294.0 Min 548.0 690.0 548.0 612.0 612.0 Max 2255.0 2024.0 2255.0 2140.0 2140.0 Age at discharge (days) Median 262.0 261.0 261.5 257.0 259.0 Min 243.0 243.0 243.0 245.0 243.0 Max 319.0 297.0 319.0 286.0 297.0 Age at DXA (years) Median 6.3 6.3 6.3 6.2 6.3 Min 5.8 5.8 5.8 5.8 5.8 Max 8.3 7.7 8.3 7.2 7.7 Weight at DXA (kg) Median 21.5 20.8 21.1 21.4 21.0 Min 16.0 13.9 13.9 16.8 13.9 Max 35.1 33.8 35.1 40.0 40.0 Weight growth (Z-score dif. from GA 34 to 2 months CA) Mean 0.79 0.96 0.88 1.31 1.13 0.28 0.002* 0.01* SD 0.87 0.88 0.87 0.91 0.91 Weight z-score DXA Mean −0.16 −0.40 −0.29 −0.09 −0.24 0.22 0.27 0.62 SD 1.06 1.14 1.10 1.24 1.20 Height at DXA (cm) Mean 120.61 119.56 120.05 118.97 119.27 0.28 0.18 0.12 SD 5.56 5.16 5.35 5.23 5.19 Height z-score DXA Mean 0.11 0.01 0.06 −0.10 −0.04 0.58 0.31 0.32 SD 0.99 1.10 1.04 1.00 1.05 LBM Mean 9.75 9.71 9.73 9.73 9.72 0.10 0.79 0.12 SD 0.14 0.13 0.13 0.13 0.12 FM Mean 8.03 8.02 8.02 8.14 8.08 0.90 0.15 0.55 SD 0.53 0.52 0.52 0.57 0.54 GA = gestational age and BW = birth weight, no significant difference comparing groups. CA = corrected age, LBM = lean body mass, FM = fat mass, n = numbers The original article has been corrected.
U2 - 10.1007/s00431-025-06045-4
DO - 10.1007/s00431-025-06045-4
M3 - Comment/debate
C2 - 40042625
AN - SCOPUS:86000356100
SN - 0340-6199
VL - 184
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 3
M1 - 224
ER -