Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis

R. B. Dessau*, G. Lisby, J. L. Frederiksen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Abstract

Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS. Material and methods - Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43. Results - Four patients and 1 control were positive for HCV-229E. No evidence of HCV-OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls. Conclusion - This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.

Original languageEnglish
Title of host publicationActa Nerurologica Scandinavica
Number of pages4
Volume100
Publication date22. Jul 1999
Edition2
Pages88-91
Publication statusPublished - 22. Jul 1999
SeriesActa Neurologica Scandinavica
ISSN0001-6314

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Optic Neuritis
Coronavirus
Human Coronavirus OC43
Human Coronavirus 229E
Multiplex Polymerase Chain Reaction
RNA
Polymerase Chain Reaction

Keywords

  • Human coronavirus
  • Multiple sclerosis
  • Optic neuritis
  • Polymerase chain reaction

Cite this

Dessau, R. B., Lisby, G., & Frederiksen, J. L. (1999). Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis. In Acta Nerurologica Scandinavica (2 ed., Vol. 100, pp. 88-91). Acta Neurologica Scandinavica
Dessau, R. B. ; Lisby, G. ; Frederiksen, J. L. / Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis. Acta Nerurologica Scandinavica. Vol. 100 2. ed. 1999. pp. 88-91 (Acta Neurologica Scandinavica).
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Dessau, RB, Lisby, G & Frederiksen, JL 1999, Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis. in Acta Nerurologica Scandinavica. 2 edn, vol. 100, Acta Neurologica Scandinavica, pp. 88-91.

Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis. / Dessau, R. B.; Lisby, G.; Frederiksen, J. L.

Acta Nerurologica Scandinavica. Vol. 100 2. ed. 1999. p. 88-91 (Acta Neurologica Scandinavica).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

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AU - Frederiksen, J. L.

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N2 - Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS. Material and methods - Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43. Results - Four patients and 1 control were positive for HCV-229E. No evidence of HCV-OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls. Conclusion - This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.

AB - Acute monosymptomatic optic neuritis (AMON) may be an initial symptom of multiple sclerosis (MS). Coronaviruses have been implicated in the etiology of MS. The objective of the present study was to look for coronaviral RNA in AMON, which could be present in the initial stages of the development of MS. Material and methods - Spinal fluids from 37 patients with AMON and 15 surgical control patients with protrusion of the intervertebral disk were assayed with a nested multiplex polymerase chain reaction with primers specific for human coronaviruses strain (HCV) 229E and OC43. Results - Four patients and 1 control were positive for HCV-229E. No evidence of HCV-OC43 was found. The frequency of positive samples was low and there was no statistical difference between AMON and controls. Conclusion - This study does not provide evidence for an etiological role of human coronaviruses in acute monosymptomatic optic neuritis.

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Dessau RB, Lisby G, Frederiksen JL. Coronaviruses in spinal fluid of patients with acute monosymptomatic optic neuritis. In Acta Nerurologica Scandinavica. 2 ed. Vol. 100. 1999. p. 88-91. (Acta Neurologica Scandinavica).