Coronary CT Angiography Derived Fractional Flow Reserve: The Game Changer in Noninvasive Testing

Bjarne Linde Nørgaard*, Jesper Møller Jensen, Philipp Blanke, Niels Peter Sand, Mark Rabbat, Jonathon Leipsic

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Purpose of Review: To summarize the scientific basis of CT derived fractional flow reserve (FFRCT) and present an updated review on the evidence from clinical trials and real-world observational data Recent Findings: In prospective multicenter studies of patients with stable coronary artery disease (CAD), FFRCT showed high diagnostic performance. More recently, FFRCT has advanced to the realm of clinical utility and real-world clinical practice with emerging data showing that FFRCT when compared to standard care is efficient in safely reducing downstream utilization of invasive coronary angiography (ICA), and costs, as well as improving the diagnostic yield of ICA. Moreover, FFRCT may broaden applicability of frontline coronary CTA testing to patients with high pre-test risk of CAD. Summary: Introducing FFRCT into clinical practice has the potential to significantly improve the management of patients with stable CAD. The optimal FFRCT testing interpretation strategy, as well as the relative cost-efficiency of FFRCT against standard noninvasive functional testing, need further investigation.

Original languageEnglish
Article number112
JournalCurrent Cardiology Reports
Volume19
Number of pages10
ISSN1523-3782
DOIs
Publication statusPublished - 2017

Fingerprint

Coronary Angiography
Coronary Artery Disease
Multicenter Studies
Prospective Studies
Computed Tomography Angiography

Keywords

  • Coronary artery disease
  • coronary computed tomography angiography
  • fractional flow reserve

Cite this

Nørgaard, Bjarne Linde ; Jensen, Jesper Møller ; Blanke, Philipp ; Sand, Niels Peter ; Rabbat, Mark ; Leipsic, Jonathon. / Coronary CT Angiography Derived Fractional Flow Reserve : The Game Changer in Noninvasive Testing. In: Current Cardiology Reports. 2017 ; Vol. 19.
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abstract = "Purpose of Review: To summarize the scientific basis of CT derived fractional flow reserve (FFRCT) and present an updated review on the evidence from clinical trials and real-world observational data Recent Findings: In prospective multicenter studies of patients with stable coronary artery disease (CAD), FFRCT showed high diagnostic performance. More recently, FFRCT has advanced to the realm of clinical utility and real-world clinical practice with emerging data showing that FFRCT when compared to standard care is efficient in safely reducing downstream utilization of invasive coronary angiography (ICA), and costs, as well as improving the diagnostic yield of ICA. Moreover, FFRCT may broaden applicability of frontline coronary CTA testing to patients with high pre-test risk of CAD. Summary: Introducing FFRCT into clinical practice has the potential to significantly improve the management of patients with stable CAD. The optimal FFRCT testing interpretation strategy, as well as the relative cost-efficiency of FFRCT against standard noninvasive functional testing, need further investigation.",
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Coronary CT Angiography Derived Fractional Flow Reserve : The Game Changer in Noninvasive Testing. / Nørgaard, Bjarne Linde; Jensen, Jesper Møller; Blanke, Philipp; Sand, Niels Peter; Rabbat, Mark; Leipsic, Jonathon.

In: Current Cardiology Reports, Vol. 19, 112, 2017.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Coronary CT Angiography Derived Fractional Flow Reserve

T2 - The Game Changer in Noninvasive Testing

AU - Nørgaard, Bjarne Linde

AU - Jensen, Jesper Møller

AU - Blanke, Philipp

AU - Sand, Niels Peter

AU - Rabbat, Mark

AU - Leipsic, Jonathon

PY - 2017

Y1 - 2017

N2 - Purpose of Review: To summarize the scientific basis of CT derived fractional flow reserve (FFRCT) and present an updated review on the evidence from clinical trials and real-world observational data Recent Findings: In prospective multicenter studies of patients with stable coronary artery disease (CAD), FFRCT showed high diagnostic performance. More recently, FFRCT has advanced to the realm of clinical utility and real-world clinical practice with emerging data showing that FFRCT when compared to standard care is efficient in safely reducing downstream utilization of invasive coronary angiography (ICA), and costs, as well as improving the diagnostic yield of ICA. Moreover, FFRCT may broaden applicability of frontline coronary CTA testing to patients with high pre-test risk of CAD. Summary: Introducing FFRCT into clinical practice has the potential to significantly improve the management of patients with stable CAD. The optimal FFRCT testing interpretation strategy, as well as the relative cost-efficiency of FFRCT against standard noninvasive functional testing, need further investigation.

AB - Purpose of Review: To summarize the scientific basis of CT derived fractional flow reserve (FFRCT) and present an updated review on the evidence from clinical trials and real-world observational data Recent Findings: In prospective multicenter studies of patients with stable coronary artery disease (CAD), FFRCT showed high diagnostic performance. More recently, FFRCT has advanced to the realm of clinical utility and real-world clinical practice with emerging data showing that FFRCT when compared to standard care is efficient in safely reducing downstream utilization of invasive coronary angiography (ICA), and costs, as well as improving the diagnostic yield of ICA. Moreover, FFRCT may broaden applicability of frontline coronary CTA testing to patients with high pre-test risk of CAD. Summary: Introducing FFRCT into clinical practice has the potential to significantly improve the management of patients with stable CAD. The optimal FFRCT testing interpretation strategy, as well as the relative cost-efficiency of FFRCT against standard noninvasive functional testing, need further investigation.

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KW - coronary computed tomography angiography

KW - fractional flow reserve

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