Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress

Bjarne Linde Nørgaard, Jonathon Leipsic, Bon-Kwon Koo, Christopher K. Zarins, Niels Peter Sand, Jesper Møller Jensen, Charles A Taylor

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Fractional flow reserve (FFR) measured during invasive coronary angiography is an independent prognosticator in patients with coronary artery disease and the gold standard for decision making in coronary revascularization. The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFRCT) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.

Original languageEnglish
Article number2
JournalCurrent Cardiovascular Imaging Reports
Volume9
Number of pages12
ISSN1941-9066
DOIs
Publication statusPublished - 2016

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Patient Simulation
Atherosclerotic Plaques
Hydrodynamics
Coronary Angiography
Coronary Artery Disease
Computed Tomography Angiography
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Nørgaard, Bjarne Linde ; Leipsic, Jonathon ; Koo, Bon-Kwon ; Zarins, Christopher K. ; Sand, Niels Peter ; Jensen, Jesper Møller ; Taylor, Charles A. / Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress. In: Current Cardiovascular Imaging Reports. 2016 ; Vol. 9.
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Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress. / Nørgaard, Bjarne Linde; Leipsic, Jonathon; Koo, Bon-Kwon; Zarins, Christopher K.; Sand, Niels Peter; Jensen, Jesper Møller ; Taylor, Charles A.

In: Current Cardiovascular Imaging Reports, Vol. 9, 2, 2016.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Leipsic, Jonathon

AU - Koo, Bon-Kwon

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AU - Sand, Niels Peter

AU - Jensen, Jesper Møller

AU - Taylor, Charles A

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