Coronary artery calcification and ECG pattern of left ventricular hypertrophy or strain identify different healthy individuals at risk

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Abstract

PURPOSE:: To improve risk stratification for development of ischaemic heart disease, several markers have been proposed. Both the presence of coronary artery calcification (CAC) and ECG pattern of left ventricular hypertrophy/strain have been shown to provide independent prognostic information. In this study, we investigated the association between established risk factors, ECG measurements and the presence of coronary artery calcification. METHOD:: A random sample of healthy men and women aged 50 or 60 years were invited to the screening study. Established risk factors were measured. A noncontrast computed tomographic (CT) scan was performed to assess the CAC score. ECG analysis included left ventricular hypertrophy (LVH) using the Sokolow-Lyon criteria and the Cornell voltage × QRS duration product, and strain pattern based on ST segment depression and T-wave abnormalities. The association between the presence of CAC, clinical variables and ECG findings was evaluated by means of multivariate logistic regression. RESULTS:: Of 1825 invited individuals, 1226 accepted the screening. The prevalence of hypertension was 50%. Hypertensive patients frequently had LVH and/or strain when compared with nonhypertensive individuals (21 vs. 14%, P 
Original languageEnglish
JournalJournal of Hypertension
Volume31
Issue number3
Pages (from-to)595-600
Number of pages6
ISSN0263-6352
DOIs
Publication statusPublished - 2013

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Left Ventricular Hypertrophy
Electrocardiography
Logistic Models

Keywords

  • Atherosclerosis
  • Coronary artery calcification
  • ECG
  • Left ventricular hypertrophy
  • Risk factors
  • Humans
  • Middle Aged
  • Risk Factors
  • Male
  • Calcinosis
  • Electrocardiography
  • Female
  • Hypertrophy, Left Ventricular/physiopathology
  • Coronary Vessels/pathology

Cite this

@article{edfbccdd70134ef68fd7a1491076062c,
title = "Coronary artery calcification and ECG pattern of left ventricular hypertrophy or strain identify different healthy individuals at risk",
abstract = "PURPOSE:: To improve risk stratification for development of ischaemic heart disease, several markers have been proposed. Both the presence of coronary artery calcification (CAC) and ECG pattern of left ventricular hypertrophy/strain have been shown to provide independent prognostic information. In this study, we investigated the association between established risk factors, ECG measurements and the presence of coronary artery calcification. METHOD:: A random sample of healthy men and women aged 50 or 60 years were invited to the screening study. Established risk factors were measured. A noncontrast computed tomographic (CT) scan was performed to assess the CAC score. ECG analysis included left ventricular hypertrophy (LVH) using the Sokolow-Lyon criteria and the Cornell voltage × QRS duration product, and strain pattern based on ST segment depression and T-wave abnormalities. The association between the presence of CAC, clinical variables and ECG findings was evaluated by means of multivariate logistic regression. RESULTS:: Of 1825 invited individuals, 1226 accepted the screening. The prevalence of hypertension was 50{\%}. Hypertensive patients frequently had LVH and/or strain when compared with nonhypertensive individuals (21 vs. 14{\%}, P ",
keywords = "Atherosclerosis, Coronary artery calcification, ECG, Left ventricular hypertrophy, Risk factors, Humans, Middle Aged, Risk Factors, Male, Calcinosis, Electrocardiography, Female, Hypertrophy, Left Ventricular/physiopathology, Coronary Vessels/pathology",
author = "Diederichsen, {S{\o}ren Z{\"o}ga} and Oke Gerke and Olsen, {Michael Hecht} and Jess Lambrechtsen and Sand, {Niels Peter R{\o}nnow} and N{\o}rgaard, {Bjarne Linde} and Hans Mickley and Diederichsen, {Axel Cosmus Pyndt}",
year = "2013",
doi = "10.1097/HJH.0b013e32835cb47e",
language = "English",
volume = "31",
pages = "595--600",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "3",

}

TY - JOUR

T1 - Coronary artery calcification and ECG pattern of left ventricular hypertrophy or strain identify different healthy individuals at risk

AU - Diederichsen, Søren Zöga

AU - Gerke, Oke

AU - Olsen, Michael Hecht

AU - Lambrechtsen, Jess

AU - Sand, Niels Peter Rønnow

AU - Nørgaard, Bjarne Linde

AU - Mickley, Hans

AU - Diederichsen, Axel Cosmus Pyndt

PY - 2013

Y1 - 2013

N2 - PURPOSE:: To improve risk stratification for development of ischaemic heart disease, several markers have been proposed. Both the presence of coronary artery calcification (CAC) and ECG pattern of left ventricular hypertrophy/strain have been shown to provide independent prognostic information. In this study, we investigated the association between established risk factors, ECG measurements and the presence of coronary artery calcification. METHOD:: A random sample of healthy men and women aged 50 or 60 years were invited to the screening study. Established risk factors were measured. A noncontrast computed tomographic (CT) scan was performed to assess the CAC score. ECG analysis included left ventricular hypertrophy (LVH) using the Sokolow-Lyon criteria and the Cornell voltage × QRS duration product, and strain pattern based on ST segment depression and T-wave abnormalities. The association between the presence of CAC, clinical variables and ECG findings was evaluated by means of multivariate logistic regression. RESULTS:: Of 1825 invited individuals, 1226 accepted the screening. The prevalence of hypertension was 50%. Hypertensive patients frequently had LVH and/or strain when compared with nonhypertensive individuals (21 vs. 14%, P 

AB - PURPOSE:: To improve risk stratification for development of ischaemic heart disease, several markers have been proposed. Both the presence of coronary artery calcification (CAC) and ECG pattern of left ventricular hypertrophy/strain have been shown to provide independent prognostic information. In this study, we investigated the association between established risk factors, ECG measurements and the presence of coronary artery calcification. METHOD:: A random sample of healthy men and women aged 50 or 60 years were invited to the screening study. Established risk factors were measured. A noncontrast computed tomographic (CT) scan was performed to assess the CAC score. ECG analysis included left ventricular hypertrophy (LVH) using the Sokolow-Lyon criteria and the Cornell voltage × QRS duration product, and strain pattern based on ST segment depression and T-wave abnormalities. The association between the presence of CAC, clinical variables and ECG findings was evaluated by means of multivariate logistic regression. RESULTS:: Of 1825 invited individuals, 1226 accepted the screening. The prevalence of hypertension was 50%. Hypertensive patients frequently had LVH and/or strain when compared with nonhypertensive individuals (21 vs. 14%, P 

KW - Atherosclerosis

KW - Coronary artery calcification

KW - ECG

KW - Left ventricular hypertrophy

KW - Risk factors

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Male

KW - Calcinosis

KW - Electrocardiography

KW - Female

KW - Hypertrophy, Left Ventricular/physiopathology

KW - Coronary Vessels/pathology

U2 - 10.1097/HJH.0b013e32835cb47e

DO - 10.1097/HJH.0b013e32835cb47e

M3 - Journal article

C2 - 23462709

VL - 31

SP - 595

EP - 600

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 3

ER -