Cooling crystallization of Indomethacin from different organic solvents

Chandrakant Ramkrishna Malwade, Haiyan Qu

Research output: Contribution to conference without publisher/journalPaperResearchpeer-review

Abstract

In the present work, crystallization of an anti-inflammatory drug Indomethacin (IMC) from different organic solvents was investigated concerning the polymorphism and particulate properties of the final product. Initially, the solvents were screened by measuring solubility of IMC at temperatures 15, 25, 35, and 45 °C. The solvents with varying polarities (ethanol, methanol, ethyl acetate, acetone, acetonitrile, and dichloromethane) were used for solubility measurement. Maximum solubility of IMC was observed in acetone, while acetonitrile showed the lowest solubility. Solid phase analysis of excess solute with XRPD and Raman spectroscopy confirmed formation of IMC solvate in acetone, methanol and dichloromethane at 15 °C. Based on solubility of IMC, the solvents ethanol, ethyl acetate, acetone, and dichloromethane were selected for crystallization experiments. Nucleation kinetics of IMC in selected solvents was investigated through the measurement of induction time at 5 °C and 15 °C. Longer induction times were observed for IMC in ethanol at both temperatures compared to the one in acetone. Metastable α form of IMC was obtained from ethanol, while solvate of IMC was produced from acetone.
Original languageEnglish
Publication date2017
Number of pages6
Publication statusPublished - 2017
Event24th International Symposium on Industrial Crystallization - Technical University, Dortmund, Germany
Duration: 29. Aug 201731. Aug 2017
http://www.apt.bci.tu-dortmund.de/cms/en/BIWIC2017/index.html

Conference

Conference24th International Symposium on Industrial Crystallization
LocationTechnical University
CountryGermany
CityDortmund
Period29/08/201731/08/2017
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Malwade, C. R., & Qu, H. (2017). Cooling crystallization of Indomethacin from different organic solvents. Paper presented at 24th International Symposium on Industrial Crystallization, Dortmund, Germany.