In the present work, crystallization of an anti-inflammatory drug Indomethacin (IMC) from different organic solvents was investigated concerning the polymorphism and particulate properties of the final product. Initially, the solvents were screened by measuring solubility of IMC at temperatures 15, 25, 35, and 45 °C. The solvents with varying polarities (ethanol, methanol, ethyl acetate, acetone, acetonitrile, and dichloromethane) were used for solubility measurement. Maximum solubility of IMC was observed in acetone, while acetonitrile showed the lowest solubility. Solid phase analysis of excess solute with XRPD and Raman spectroscopy confirmed formation of IMC solvate in acetone, methanol and dichloromethane at 15 °C. Based on solubility of IMC, the solvents ethanol, ethyl acetate, acetone, and dichloromethane were selected for crystallization experiments. Nucleation kinetics of IMC in selected solvents was investigated through the measurement of induction time at 5 °C and 15 °C. Longer induction times were observed for IMC in ethanol at both temperatures compared to the one in acetone. Metastable α form of IMC was obtained from ethanol, while solvate of IMC was produced from acetone.
|Number of pages||6|
|Publication status||Published - 2017|
|Event||24th International Symposium on Industrial Crystallization - Technical University, Dortmund, Germany|
Duration: 29. Aug 2017 → 31. Aug 2017
|Conference||24th International Symposium on Industrial Crystallization|
|Period||29/08/2017 → 31/08/2017|
Malwade, C. R., & Qu, H. (2017). Cooling crystallization of Indomethacin from different organic solvents. Paper presented at 24th International Symposium on Industrial Crystallization, Dortmund, Germany.