Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

V. E. Gruzdev; D. Korkin; B. P. Mooney; J. F. Havelund; I. M. Møller; J. J. Thelen

doi:10.1109/LO.2018.8435786

Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

V. E. Gruzdev, D. Korkin, B. P. Mooney, J. F. Havelund, I. M. Møller, J. J. Thelen

Department of Biochemistry and Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

Original language	English
Title of host publication	Proceedings - International Conference Laser Optics 2018 : ICLO 2018
Number of pages	1
Publisher	IEEE
Publication date	Aug 2018
Article number	8435786
ISBN (Print)	9781538636121
DOIs	https://doi.org/10.1109/LO.2018.8435786
Publication status	Published - Aug 2018
Event	2018 International Conference Laser Optics, ICLO 2018 - St. Petersburg, Russian Federation Duration: 4. Jun 2018 → 8. Jun 2018

Conference

Conference	2018 International Conference Laser Optics, ICLO 2018
Country/Territory	Russian Federation
City	St. Petersburg
Period	04/06/2018 → 08/06/2018

Keywords

Biochemistry
Molecular biophysics
Peptide
Photochemistry
Protein engineering
Proteins

Documents & Links

10.1109/LO.2018.8435786

Cite this

@inproceedings{40bd391b0e4c4a98b33b05d83cce45ae,

title = "Controlled chemical modification of biomolecules by femtosecond laser in polar liquids",

abstract = "Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.",

keywords = "Biochemistry, Molecular biophysics, Peptide, Photochemistry, Protein engineering, Proteins",

author = "Gruzdev, {V. E.} and D. Korkin and Mooney, {B. P.} and Havelund, {J. F.} and M{\o}ller, {I. M.} and Thelen, {J. J.}",

year = "2018",

month = aug,

doi = "10.1109/LO.2018.8435786",

language = "English",

isbn = "9781538636121",

booktitle = "Proceedings - International Conference Laser Optics 2018",

publisher = "IEEE",

address = "United States",

note = "2018 International Conference Laser Optics, ICLO 2018 ; Conference date: 04-06-2018 Through 08-06-2018",

}

Gruzdev, VE, Korkin, D, Mooney, BP, Havelund, JF, Møller, IM & Thelen, JJ 2018, Controlled chemical modification of biomolecules by femtosecond laser in polar liquids. in Proceedings - International Conference Laser Optics 2018: ICLO 2018., 8435786, IEEE, 2018 International Conference Laser Optics, ICLO 2018, St. Petersburg, Russian Federation, 04/06/2018. https://doi.org/10.1109/LO.2018.8435786

TY - GEN

T1 - Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

AU - Gruzdev, V. E.

AU - Korkin, D.

AU - Mooney, B. P.

AU - Havelund, J. F.

AU - Møller, I. M.

AU - Thelen, J. J.

PY - 2018/8

Y1 - 2018/8

N2 - Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

AB - Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

KW - Biochemistry

KW - Molecular biophysics

KW - Peptide

KW - Photochemistry

KW - Protein engineering

KW - Proteins

U2 - 10.1109/LO.2018.8435786

DO - 10.1109/LO.2018.8435786

M3 - Article in proceedings

AN - SCOPUS:85052507930

SN - 9781538636121

BT - Proceedings - International Conference Laser Optics 2018

PB - IEEE

T2 - 2018 International Conference Laser Optics, ICLO 2018

Y2 - 4 June 2018 through 8 June 2018

ER -

Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

Abstract

Conference

Keywords

Documents & Links

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