Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

Charlotte Nielsen Agergaard; Lone Jannok Porsbo; Thomas Vognbjerg Sydenham; Sanne Grønvall Kjær Hansen; Kat Steinke; Sanne Løkkegaard Larsen; Kristján Orri Helgason; Frank Hansen; Kasper Thystrup Karstensen; Anna E. Henius; Barbara Juliane Holzknecht; Lillian Søes; Kristian Schønning; Mikala Wang; Nina Ank; Anna Margrét Halldórsdóttir; Ólafur Guðlaugsson; Anette M. Hammerum; Anne Kjerulf; Brian Kristensen; Henrik Hasman; Ulrik Stenz Justesen

doi:10.2807/1560-7917.ES.2023.28.9.2300108

Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

Charlotte Nielsen Agergaard, Lone Jannok Porsbo, Thomas Vognbjerg Sydenham, Sanne Grønvall Kjær Hansen, Kat Steinke, Sanne Løkkegaard Larsen, Kristján Orri Helgason, Frank Hansen, Kasper Thystrup Karstensen, Anna E. Henius, Barbara Juliane Holzknecht, Lillian Søes, Kristian Schønning, Mikala Wang, Nina Ank, Anna Margrét Halldórsdóttir, Ólafur Guðlaugsson, Anette M. Hammerum, Anne Kjerulf, Brian KristensenHenrik Hasman, Ulrik Stenz Justesen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.

Original language	English
Article number	pii=2300108
Journal	Eurosurveillance
Volume	28
Issue number	9
Number of pages	4
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2023.28.9.2300108
Publication status	Published - 1. Mar 2023

Keywords

antibiotic
CPO
dicloxacillin
Enterobacter hormaechei
Outbreak

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10.2807/1560-7917.ES.2023.28.9.2300108Licence: CC BY

Open Access VersionFinal published version, 234 KBLicence: CC BY

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Agergaard, C. N., Porsbo, L. J., Sydenham, T. V., Hansen, S. G. K., Steinke, K., Larsen, S. L., Helgason, K. O., Hansen, F., Karstensen, K. T., Henius, A. E., Holzknecht, B. J., Søes, L., Schønning, K., Wang, M., Ank, N., Halldórsdóttir, A. M., Guðlaugsson, Ó., Hammerum, A. M., Kjerulf, A., ... Justesen, U. S. (2023). Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023. Eurosurveillance, 28(9), Article pii=2300108. https://doi.org/10.2807/1560-7917.ES.2023.28.9.2300108

@article{893a484cb7e149f6b4f08b56034f72b7,

title = "Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023",

abstract = "From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.",

keywords = "antibiotic, CPO, dicloxacillin, Enterobacter hormaechei, Outbreak",

author = "Agergaard, {Charlotte Nielsen} and Porsbo, {Lone Jannok} and Sydenham, {Thomas Vognbjerg} and Hansen, {Sanne Gr{\o}nvall Kj{\ae}r} and Kat Steinke and Larsen, {Sanne L{\o}kkegaard} and Helgason, {Kristj{\'a}n Orri} and Frank Hansen and Karstensen, {Kasper Thystrup} and Henius, {Anna E.} and Holzknecht, {Barbara Juliane} and Lillian S{\o}es and Kristian Sch{\o}nning and Mikala Wang and Nina Ank and Halld{\'o}rsd{\'o}ttir, {Anna Margr{\'e}t} and {\'O}lafur Gu{\dh}laugsson and Hammerum, {Anette M.} and Anne Kjerulf and Brian Kristensen and Henrik Hasman and Justesen, {Ulrik Stenz}",

year = "2023",

month = mar,

day = "1",

doi = "10.2807/1560-7917.ES.2023.28.9.2300108",

language = "English",

volume = "28",

journal = "Eurosurveillance",

issn = "1560-7917",

publisher = "European Centre for Disease Prevention and Control",

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Agergaard, CN, Porsbo, LJ, Sydenham, TV , Hansen, SGK , Steinke, K , Larsen, SL, Helgason, KO, Hansen, F, Karstensen, KT, Henius, AE, Holzknecht, BJ, Søes, L, Schønning, K, Wang, M, Ank, N, Halldórsdóttir, AM, Guðlaugsson, Ó, Hammerum, AM, Kjerulf, A, Kristensen, B, Hasman, H & Justesen, US 2023, 'Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023', Eurosurveillance, vol. 28, no. 9, pii=2300108. https://doi.org/10.2807/1560-7917.ES.2023.28.9.2300108

Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023. / Agergaard, Charlotte Nielsen; Porsbo, Lone Jannok; Sydenham, Thomas Vognbjerg et al.
In: Eurosurveillance, Vol. 28, No. 9, pii=2300108, 01.03.2023.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

AU - Agergaard, Charlotte Nielsen

AU - Porsbo, Lone Jannok

AU - Sydenham, Thomas Vognbjerg

AU - Hansen, Sanne Grønvall Kjær

AU - Steinke, Kat

AU - Larsen, Sanne Løkkegaard

AU - Helgason, Kristján Orri

AU - Hansen, Frank

AU - Karstensen, Kasper Thystrup

AU - Henius, Anna E.

AU - Holzknecht, Barbara Juliane

AU - Søes, Lillian

AU - Schønning, Kristian

AU - Wang, Mikala

AU - Ank, Nina

AU - Halldórsdóttir, Anna Margrét

AU - Guðlaugsson, Ólafur

AU - Hammerum, Anette M.

AU - Kjerulf, Anne

AU - Kristensen, Brian

AU - Hasman, Henrik

AU - Justesen, Ulrik Stenz

PY - 2023/3/1

Y1 - 2023/3/1

N2 - From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.

AB - From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.

KW - antibiotic

KW - CPO

KW - dicloxacillin

KW - Enterobacter hormaechei

KW - Outbreak

U2 - 10.2807/1560-7917.ES.2023.28.9.2300108

DO - 10.2807/1560-7917.ES.2023.28.9.2300108

M3 - Journal article

C2 - 36862098

AN - SCOPUS:85149305071

SN - 1560-7917

VL - 28

JO - Eurosurveillance

JF - Eurosurveillance

IS - 9

M1 - pii=2300108

ER -

Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

Abstract

Keywords

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