Condensing the information in DNA with double-headed nucleotides

Mick Hornum, Pawan K Sharma, Charlotte Reslow-Jacobsen, Pawan Kumar, Michael Petersen, Poul Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

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A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

Original languageEnglish
JournalChemical Communications
Issue number70
Pages (from-to)9717-9720
Number of pages4
Publication statusPublished - 2017


  • Journal Article


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