Condensing the information in DNA with double-headed nucleotides

Mick Hornum, Pawan K Sharma, Charlotte Reslow-Jacobsen, Pawan Kumar, Michael Petersen, Poul Nielsen

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Abstract

A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

Original languageEnglish
JournalChemical Communications
Volume53
Issue number70
Pages (from-to)9717-9720
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 2017

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Nucleotides
DNA
Phosphates

Keywords

  • Journal Article

Cite this

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title = "Condensing the information in DNA with double-headed nucleotides",
abstract = "A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.",
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Condensing the information in DNA with double-headed nucleotides. / Hornum, Mick; Sharma, Pawan K; Reslow-Jacobsen, Charlotte; Kumar, Pawan; Petersen, Michael; Nielsen, Poul.

In: Chemical Communications, Vol. 53, No. 70, 2017, p. 9717-9720.

Research output: Contribution to journalLetterResearchpeer-review

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T1 - Condensing the information in DNA with double-headed nucleotides

AU - Hornum, Mick

AU - Sharma, Pawan K

AU - Reslow-Jacobsen, Charlotte

AU - Kumar, Pawan

AU - Petersen, Michael

AU - Nielsen, Poul

PY - 2017

Y1 - 2017

N2 - A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

AB - A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

KW - Journal Article

U2 - 10.1039/c7cc05047j

DO - 10.1039/c7cc05047j

M3 - Letter

C2 - 28820207

VL - 53

SP - 9717

EP - 9720

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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