Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals

Martin Bonde Jensen, Casper Slots, Nicholas Ditzel, Ole Albrektsen, Søren Wiatr Borg, Torben Thygesen, Moustapha Kassem, Morten Østergaard Andersen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

216 Downloads (Pure)

Abstract

This paper introduces a novel class of resorbable implant materials based on composites of solid fatty acids and ceramic powders. The materials could be 3D printed and cast into implants that consisted of powder particles embedded in a dense and solid lipid matrix. The implants possessed 10x higher compressive strengths than pure fatty acids and their compressive strength, resorption speed and drug release rate could be controlled by varying the fatty acid tail length. The materials supported the attachment and growth of mesenchymal stem cells in vitro and when implanted in a subcutaneous mouse model they were found to be biocompatible and support the formation of cellularized and vascularized tissue in vivo. These results indicate that solid fatty acid/ceramic matrices may be used as a biomaterial for structural implants and controlled release drug depots providing an attractive alternative to the polymer based matrices commonly used for such implants.

Original languageEnglish
Article numbere00027
JournalBioprinting
Volume10
ISSN2405-8866
DOIs
Publication statusPublished - Jun 2018

Keywords

  • 3D printing
  • Additive manufacturing
  • Controlled release
  • Fatty acids
  • Scaffolds
  • Tricalcium phosphate

Fingerprint

Dive into the research topics of 'Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals'. Together they form a unique fingerprint.

Cite this