Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults

Pia Christensen, Rikke Frederiksen, Henning Bliddal, Birgit F Riecke, Else M Bartels, Marius Henriksen, Tina Juul Sørensen, Henrik Gudbergsen, Kaj Winther, Arne Astrup, Robin Christensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk-factors, nutritional health, and body composition after 1-year weight-loss maintenance achieved by [D]diet, [E]knee-exercise, or [C]control, following weight loss by low-energy-diet. DESIGN AND METHODS: Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body-mass index 37.3 kg/m(2) (4.8), were enrolled into a 68-week weight-loss trial. RESULTS: Mean changes in weight, in D, E, and C were -11.0, -6.3, and -8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were -8.4, -4.6, and -7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: -3.8 cm (95%CI -6.2 to -1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups. CONCLUSIONS: Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.
Original languageEnglish
JournalObesity
Volume21
Issue number10
Pages (from-to)1982–1990
ISSN1930-7381
DOIs
Publication statusPublished - Oct 2013

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Vitamins
Knee Osteoarthritis
Maintenance
Weights and Measures
Diet
Health
Knee
Body Mass Index
Exercise

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Christensen, P., Frederiksen, R., Bliddal, H., Riecke, B. F., Bartels, E. M., Henriksen, M., ... Christensen, R. (2013). Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults. Obesity, 21(10), 1982–1990. https://doi.org/10.1002/oby.20413
Christensen, Pia ; Frederiksen, Rikke ; Bliddal, Henning ; Riecke, Birgit F ; Bartels, Else M ; Henriksen, Marius ; Sørensen, Tina Juul ; Gudbergsen, Henrik ; Winther, Kaj ; Astrup, Arne ; Christensen, Robin. / Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults. In: Obesity. 2013 ; Vol. 21, No. 10. pp. 1982–1990.
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title = "Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults",
abstract = "OBJECTIVE: Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk-factors, nutritional health, and body composition after 1-year weight-loss maintenance achieved by [D]diet, [E]knee-exercise, or [C]control, following weight loss by low-energy-diet. DESIGN AND METHODS: Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body-mass index 37.3 kg/m(2) (4.8), were enrolled into a 68-week weight-loss trial. RESULTS: Mean changes in weight, in D, E, and C were -11.0, -6.3, and -8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were -8.4, -4.6, and -7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: -3.8 cm (95{\%}CI -6.2 to -1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups. CONCLUSIONS: Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.",
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Christensen, P, Frederiksen, R, Bliddal, H, Riecke, BF, Bartels, EM, Henriksen, M, Sørensen, TJ, Gudbergsen, H, Winther, K, Astrup, A & Christensen, R 2013, 'Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults', Obesity, vol. 21, no. 10, pp. 1982–1990. https://doi.org/10.1002/oby.20413

Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults. / Christensen, Pia; Frederiksen, Rikke; Bliddal, Henning; Riecke, Birgit F; Bartels, Else M; Henriksen, Marius; Sørensen, Tina Juul; Gudbergsen, Henrik; Winther, Kaj; Astrup, Arne; Christensen, Robin.

In: Obesity, Vol. 21, No. 10, 10.2013, p. 1982–1990.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults

AU - Christensen, Pia

AU - Frederiksen, Rikke

AU - Bliddal, Henning

AU - Riecke, Birgit F

AU - Bartels, Else M

AU - Henriksen, Marius

AU - Sørensen, Tina Juul

AU - Gudbergsen, Henrik

AU - Winther, Kaj

AU - Astrup, Arne

AU - Christensen, Robin

N1 - Article first published online: 13 APR 2013

PY - 2013/10

Y1 - 2013/10

N2 - OBJECTIVE: Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk-factors, nutritional health, and body composition after 1-year weight-loss maintenance achieved by [D]diet, [E]knee-exercise, or [C]control, following weight loss by low-energy-diet. DESIGN AND METHODS: Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body-mass index 37.3 kg/m(2) (4.8), were enrolled into a 68-week weight-loss trial. RESULTS: Mean changes in weight, in D, E, and C were -11.0, -6.3, and -8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were -8.4, -4.6, and -7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: -3.8 cm (95%CI -6.2 to -1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups. CONCLUSIONS: Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.

AB - OBJECTIVE: Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk-factors, nutritional health, and body composition after 1-year weight-loss maintenance achieved by [D]diet, [E]knee-exercise, or [C]control, following weight loss by low-energy-diet. DESIGN AND METHODS: Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body-mass index 37.3 kg/m(2) (4.8), were enrolled into a 68-week weight-loss trial. RESULTS: Mean changes in weight, in D, E, and C were -11.0, -6.3, and -8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were -8.4, -4.6, and -7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: -3.8 cm (95%CI -6.2 to -1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups. CONCLUSIONS: Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.

U2 - 10.1002/oby.20413

DO - 10.1002/oby.20413

M3 - Journal article

C2 - 23512743

VL - 21

SP - 1982

EP - 1990

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 10

ER -

Christensen P, Frederiksen R, Bliddal H, Riecke BF, Bartels EM, Henriksen M et al. Comparison of three different weight maintenance programs on cardiovascular risk, bone, and vitamins in sedentary older adults. Obesity. 2013 Oct;21(10):1982–1990. https://doi.org/10.1002/oby.20413