Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

Antonis Antoniou, Karoline Kuchenbaecker, Penny Soucy, Jonathan Beesley, Xiaoqing Chen, Lesley McGuffog, Andrew Lee, Daniel Barrowdale, Sue Healey, Olga Sinilnikova, Maria Caligo, Niklas Loman, Katja Harbst, Annika Lindblom, Brita Arver, Richard Rosenquist, Per Karlsson, Kate Nathanson, Susan Domchek, Tim Rebbeck & 31 others Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Elżbieta Złowowcka-Perłowska, Ana Osorio, Mercedes Durán, Raquel Andrés, Javier Benítez, Ute Hamann, Frans Hogervorst, Theo van Os, Senno Verhoef, Hanne Meijers-Heijboer, Juul Wijnen, Encarna Gómez Garcia, Marjolijn Ligtenberg, Mieke Kriege, J Margriet Collée, Margreet Ausems, Jan Oosterwijk, Susan Peock, Debra Frost, Steve Ellis, Radka Platte, Elena Fineberg, Mads Thomassen, Anne-Marie Gerdes, Anne-Bine Skytte, Torben A. Kruse, CIMBA, SWE-BRCA

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2).
Original languageEnglish
JournalBreast Cancer Research (Online Edition)
Volume14
Issue number1
Pages (from-to)R33
ISSN1465-5411
DOIs
Publication statusPublished - 2012

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Mutation
Genome-Wide Association Study
Ovarian Neoplasms
Alleles

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Antoniou, Antonis ; Kuchenbaecker, Karoline ; Soucy, Penny ; Beesley, Jonathan ; Chen, Xiaoqing ; McGuffog, Lesley ; Lee, Andrew ; Barrowdale, Daniel ; Healey, Sue ; Sinilnikova, Olga ; Caligo, Maria ; Loman, Niklas ; Harbst, Katja ; Lindblom, Annika ; Arver, Brita ; Rosenquist, Richard ; Karlsson, Per ; Nathanson, Kate ; Domchek, Susan ; Rebbeck, Tim ; Jakubowska, Anna ; Lubinski, Jan ; Jaworska, Katarzyna ; Durda, Katarzyna ; Złowowcka-Perłowska, Elżbieta ; Osorio, Ana ; Durán, Mercedes ; Andrés, Raquel ; Benítez, Javier ; Hamann, Ute ; Hogervorst, Frans ; van Os, Theo ; Verhoef, Senno ; Meijers-Heijboer, Hanne ; Wijnen, Juul ; Gómez Garcia, Encarna ; Ligtenberg, Marjolijn ; Kriege, Mieke ; Collée, J Margriet ; Ausems, Margreet ; Oosterwijk, Jan ; Peock, Susan ; Frost, Debra ; Ellis, Steve ; Platte, Radka ; Fineberg, Elena ; Thomassen, Mads ; Gerdes, Anne-Marie ; Skytte, Anne-Bine ; Kruse, Torben A. ; CIMBA, SWE-BRCA. / Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. In: Breast Cancer Research (Online Edition). 2012 ; Vol. 14, No. 1. pp. R33.
@article{59bde0be9eee48ab9345f7edee474092,
title = "Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers",
abstract = "Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2).",
author = "Antonis Antoniou and Karoline Kuchenbaecker and Penny Soucy and Jonathan Beesley and Xiaoqing Chen and Lesley McGuffog and Andrew Lee and Daniel Barrowdale and Sue Healey and Olga Sinilnikova and Maria Caligo and Niklas Loman and Katja Harbst and Annika Lindblom and Brita Arver and Richard Rosenquist and Per Karlsson and Kate Nathanson and Susan Domchek and Tim Rebbeck and Anna Jakubowska and Jan Lubinski and Katarzyna Jaworska and Katarzyna Durda and Elżbieta Złowowcka-Perłowska and Ana Osorio and Mercedes Dur{\'a}n and Raquel Andr{\'e}s and Javier Ben{\'i}tez and Ute Hamann and Frans Hogervorst and {van Os}, Theo and Senno Verhoef and Hanne Meijers-Heijboer and Juul Wijnen and {G{\'o}mez Garcia}, Encarna and Marjolijn Ligtenberg and Mieke Kriege and Coll{\'e}e, {J Margriet} and Margreet Ausems and Jan Oosterwijk and Susan Peock and Debra Frost and Steve Ellis and Radka Platte and Elena Fineberg and Mads Thomassen and Anne-Marie Gerdes and Anne-Bine Skytte and Kruse, {Torben A.} and {CIMBA, SWE-BRCA}",
year = "2012",
doi = "10.1186/bcr3121",
language = "English",
volume = "14",
pages = "R33",
journal = "Breast Cancer Research (Online Edition)",
issn = "1465-5411",
publisher = "BioMed Central",
number = "1",

}

Antoniou, A, Kuchenbaecker, K, Soucy, P, Beesley, J, Chen, X, McGuffog, L, Lee, A, Barrowdale, D, Healey, S, Sinilnikova, O, Caligo, M, Loman, N, Harbst, K, Lindblom, A, Arver, B, Rosenquist, R, Karlsson, P, Nathanson, K, Domchek, S, Rebbeck, T, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Złowowcka-Perłowska, E, Osorio, A, Durán, M, Andrés, R, Benítez, J, Hamann, U, Hogervorst, F, van Os, T, Verhoef, S, Meijers-Heijboer, H, Wijnen, J, Gómez Garcia, E, Ligtenberg, M, Kriege, M, Collée, JM, Ausems, M, Oosterwijk, J, Peock, S, Frost, D, Ellis, S, Platte, R, Fineberg, E, Thomassen, M, Gerdes, A-M, Skytte, A-B, Kruse, TA & CIMBA, SWE-BRCA 2012, 'Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers', Breast Cancer Research (Online Edition), vol. 14, no. 1, pp. R33. https://doi.org/10.1186/bcr3121

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. / Antoniou, Antonis ; Kuchenbaecker, Karoline ; Soucy, Penny; Beesley, Jonathan; Chen, Xiaoqing; McGuffog, Lesley; Lee, Andrew; Barrowdale, Daniel; Healey, Sue; Sinilnikova, Olga ; Caligo, Maria ; Loman, Niklas; Harbst, Katja; Lindblom, Annika; Arver, Brita; Rosenquist, Richard; Karlsson, Per; Nathanson, Kate; Domchek, Susan; Rebbeck, Tim; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Złowowcka-Perłowska, Elżbieta; Osorio, Ana; Durán, Mercedes; Andrés, Raquel; Benítez, Javier; Hamann, Ute; Hogervorst, Frans ; van Os, Theo ; Verhoef, Senno; Meijers-Heijboer, Hanne ; Wijnen, Juul; Gómez Garcia, Encarna ; Ligtenberg, Marjolijn ; Kriege, Mieke; Collée, J Margriet; Ausems, Margreet ; Oosterwijk, Jan ; Peock, Susan; Frost, Debra; Ellis, Steve ; Platte, Radka; Fineberg, Elena; Thomassen, Mads; Gerdes, Anne-Marie; Skytte, Anne-Bine; Kruse, Torben A. ; CIMBA, SWE-BRCA.

In: Breast Cancer Research (Online Edition), Vol. 14, No. 1, 2012, p. R33.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

AU - Antoniou, Antonis

AU - Kuchenbaecker, Karoline

AU - Soucy, Penny

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - McGuffog, Lesley

AU - Lee, Andrew

AU - Barrowdale, Daniel

AU - Healey, Sue

AU - Sinilnikova, Olga

AU - Caligo, Maria

AU - Loman, Niklas

AU - Harbst, Katja

AU - Lindblom, Annika

AU - Arver, Brita

AU - Rosenquist, Richard

AU - Karlsson, Per

AU - Nathanson, Kate

AU - Domchek, Susan

AU - Rebbeck, Tim

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Jaworska, Katarzyna

AU - Durda, Katarzyna

AU - Złowowcka-Perłowska, Elżbieta

AU - Osorio, Ana

AU - Durán, Mercedes

AU - Andrés, Raquel

AU - Benítez, Javier

AU - Hamann, Ute

AU - Hogervorst, Frans

AU - van Os, Theo

AU - Verhoef, Senno

AU - Meijers-Heijboer, Hanne

AU - Wijnen, Juul

AU - Gómez Garcia, Encarna

AU - Ligtenberg, Marjolijn

AU - Kriege, Mieke

AU - Collée, J Margriet

AU - Ausems, Margreet

AU - Oosterwijk, Jan

AU - Peock, Susan

AU - Frost, Debra

AU - Ellis, Steve

AU - Platte, Radka

AU - Fineberg, Elena

AU - Thomassen, Mads

AU - Gerdes, Anne-Marie

AU - Skytte, Anne-Bine

AU - Kruse, Torben A.

AU - CIMBA, SWE-BRCA

PY - 2012

Y1 - 2012

N2 - Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2).

AB - Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2).

U2 - 10.1186/bcr3121

DO - 10.1186/bcr3121

M3 - Journal article

VL - 14

SP - R33

JO - Breast Cancer Research (Online Edition)

JF - Breast Cancer Research (Online Edition)

SN - 1465-5411

IS - 1

ER -