Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci

Kristian Severin Rasmussen; Marianne Østergaard Poulsen; Kirstine Jacobsen; Marianne Nielsine Skov; Hans Jørn Kolmos; Birgitte H. Kallipolitis; Janne Kudsk Klitgaard

Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci

Kristian Severin Rasmussen, Marianne Østergaard Poulsen, Kirstine Jacobsen, Marianne Nielsine Skov, Hans Jørn Kolmos, Birgitte H. Kallipolitis, Janne Kudsk Klitgaard

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Synergy was observed in three of four tested VISA strains, suggesting that the thickening of cell wall does not interfere with the effects of thioridazine. In S. epidermidis, no synergy was observed in all tested strains, suggesting that synergy by combining thioridazine and dicloxacillin is isolated to S. aureus species.

Original language	English
Journal	The New Microbiologica
Volume	40
Issue number	2
Pages (from-to)	146-147
ISSN	1121-7138
Publication status	Published - Apr 2017

Keywords

Dicloxacillin.
S. aureus
S. epidermidis
Thioridazine

Documents & Links

http://www.newmicrobiologica.org/PUB/allegati_pdf/2017/2/146.pdfLicence: Unspecified

Cite this

@article{e9da7939d10e40d5b0bfdd7e74c74ccf,

title = "Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci",

abstract = "We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Synergy was observed in three of four tested VISA strains, suggesting that the thickening of cell wall does not interfere with the effects of thioridazine. In S. epidermidis, no synergy was observed in all tested strains, suggesting that synergy by combining thioridazine and dicloxacillin is isolated to S. aureus species.",

keywords = "Dicloxacillin., S. aureus, S. epidermidis, Thioridazine",

author = "{Severin Rasmussen}, Kristian and Poulsen, {Marianne {\O}stergaard} and Kirstine Jacobsen and Skov, {Marianne Nielsine} and Kolmos, {Hans J{\o}rn} and Kallipolitis, {Birgitte H.} and Klitgaard, {Janne Kudsk}",

year = "2017",

month = apr,

language = "English",

volume = "40",

pages = "146--147",

journal = "The New Microbiologica",

issn = "1121-7138",

publisher = "Edizioni Medico Scientifiche",

number = "2",

}

TY - JOUR

T1 - Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci

AU - Severin Rasmussen, Kristian

AU - Poulsen, Marianne Østergaard

AU - Jacobsen, Kirstine

AU - Skov, Marianne Nielsine

AU - Kolmos, Hans Jørn

AU - Kallipolitis, Birgitte H.

AU - Klitgaard, Janne Kudsk

PY - 2017/4

Y1 - 2017/4

N2 - We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Synergy was observed in three of four tested VISA strains, suggesting that the thickening of cell wall does not interfere with the effects of thioridazine. In S. epidermidis, no synergy was observed in all tested strains, suggesting that synergy by combining thioridazine and dicloxacillin is isolated to S. aureus species.

AB - We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Synergy was observed in three of four tested VISA strains, suggesting that the thickening of cell wall does not interfere with the effects of thioridazine. In S. epidermidis, no synergy was observed in all tested strains, suggesting that synergy by combining thioridazine and dicloxacillin is isolated to S. aureus species.

KW - Dicloxacillin.

KW - S. aureus

KW - S. epidermidis

KW - Thioridazine

M3 - Journal article

SN - 1121-7138

VL - 40

SP - 146

EP - 147

JO - The New Microbiologica

JF - The New Microbiologica

IS - 2

ER -

Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci

Abstract

Keywords

Documents & Links

Fingerprint

Cite this