Colonization and biofilm formation by Staphylococcus aureus on endothelial cell layers under flow

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Abstract

Staphylococcus aureus is a major human pathogen and known for causing vascular infections such as sepsis and infective endocarditis. It has previously been proposed that S. aureus succeed in colonization of the endothelial wall by specific surface attachment likely followed by biofilm formation. Furthermore, S. aureus is known to invade human cells, which has been proposed to promote persistence through immune and antibiotic evasion. In the current study, we sought to investigate endothelial colonization, invasion, and biofilm formation by S. aureus using a newly developed in vitro flow chamber model. We show that under physiological shear rates, S. aureus utilizes cellular invasion to enable the following surface colonization and biofilm formation. These observations might help explain the success of S. aureus as a bloodstream pathogen and guide further studies in S. aureus pathogenesis and treatment of S. aureus biofilms.
Original languageEnglish
Publication date28. May 2018
Number of pages1
Publication statusPublished - 28. May 2018
EventBiofilms8 - Aarhus University, Aarhus, Denmark
Duration: 27. May 201829. May 2018
http://conferences.au.dk/biofilms8/

Conference

ConferenceBiofilms8
LocationAarhus University
CountryDenmark
CityAarhus
Period27/05/201829/05/2018
Internet address

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Keywords

  • Biofilms
  • Pathogens
  • Staphylococcus aureus

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