Collaboration for Evidence-based Practice and Research in Anaesthesia (CEPRA): A consortium initiative for perioperative research

Anders Kehlet Nørskov*, Janus Christian Jakobsen, Arash Afshari, Jannie Bisgaard, Anja Geisler, Daniel Hägi-Pedersen, Kai Henrik Wiborg Lange, Lars Hyldborg Lundstrøm, Troels Haxholdt Lunn, Mathias Maagaard, Ann Merete Møller, Helene Korvenius Nedergaard, Lone Nikolajsen, Markus Harboe Olsen, Peter Juhl-Olsen, Bodil Steen Rasmussen, Matias Vested, Morten Vester-Andersen, Anne Wikkelsø, Ole MathiesenThe CEPRA collaboration group

*Corresponding author for this work

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Evidence in perioperative care is insufficient. There is an urgent need for large perioperative research programmes, including pragmatic randomised trials, testing daily clinical treatments and unanswered question, thereby providing solid evidence for effects of interventions given to a large and growing number of patients undergoing surgery and anaesthesia. This may be achieved through large collaborations. Collaboration for Evidence-based Practice and Research in Anaesthesia (CEPRA) is a novel collaborative research network founded to pursue evidence-based answers to major clinical questions in perioperative medicine. The aims of CEPRA are to (1) improve clinical treatment and outcomes and optimise the use of resources for patients undergoing anaesthesia and perioperative care, and (2) disseminate results and inform caretakers, patients and relatives, and policymakers of evidence-based treatments in anaesthesia and perioperative medicine. CEPRA is inclusive in its concept. We aim to extend our collaboration with all relevant clinical collaborators and patient associations and representatives. Although initiated in Denmark, CEPRA seeks to develop an international network infrastructure, for example, with other Nordic countries. The work of CEPRA will follow the highest methodological standards. The organisation aims to structure and optimise any element of the research collaboration to reduce economic costs and harness benefits from well-functioning research infrastructure. This includes successive continuation of trials, harmonisation of outcomes, and alignment of data management systems. This paper presents the initiation and visions of the CEPRA network. CEPRA aims to be inclusive, patient-focused, methodologically sound, and to optimise all aspects of research logistics. This will translate into faster research conduct, reliable results, and accelerated clinical implementation of results, thereby benefiting millions of patients whilst being cost and labour-saving.

Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Issue number6
Pages (from-to)804-810
Publication statusPublished - Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.


  • anaesthesiology
  • collaboration
  • consortium
  • methodology
  • perioperative medicine
  • Perioperative Care
  • Anesthesia/adverse effects
  • Evidence-Based Practice
  • Humans
  • Anesthesiology
  • Scandinavian and Nordic Countries


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