Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)

Svenja Specovius, Hanna G. Zimmermann, Frederike Cosima Oertel, Claudia Chien, Charlotte Bereuter, Lawrence J. Cook, Marco Aurélio Lana Peixoto, Mariana Andrade Fontenelle, Ho Jin Kim, Jae Won Hyun, Su Kyung Jung, Jacqueline Palace, Adriana Roca-Fernandez, Alejandro Rubio Diaz, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshte Ashtari, Rahele Kafieh, Alireza Dehghani, Mohsen PouraziziLekha Pandit, Anitha Dcunha, Orhan Aktas, Marius Ringelstein, Philipp Albrecht, Eugene May, Caryl Tongco, Letizia Leocani, Marco Pisa, Marta Radaelli, Elena H. Martinez-Lapiscina, Hadas Stiebel-Kalish, Mark Hellmann, Itay Lotan, Sasitorn Siritho, Jérôme de Seze, Thomas Senger, Joachim Havla, Romain Marignier, Caroline Tilikete, Alvaro Cobo Calvo, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Nasrin Asgari, Kerstin Soelberg, Ayse Altintas, Rengin Yildirim, Uygur Tanriverdi, Anu Jacob, Saif Huda, Friedemann Paul*, GJCF International Clinical Consortium for NMOSD

*Corresponding author for this work

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PURPOSE: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. PARTICIPANTS: The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. FINDINGS TO DATE: The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. FUTURE PLANS: We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.

Original languageEnglish
Article numbere035397
JournalBMJ Open
Issue number10
Number of pages9
Publication statusPublished - 29. Oct 2020


  • medical retina
  • neuro-ophthalmology
  • neurology
  • radiology & imaging


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