Cognitive tasks as provocation methods in routine EEG: a multicentre field study

Patricia Braga*, Rüta Mameniskiené, Mirian Guaranha, Eleonora Vega Zeissig, Rüta Samaitienė, Emel Ur Özcelik, Alicia Bogacz, Katia Lin, Elena Gardella, Elza Márcia Yacubian, Betül Baykan, Mariana Legnani, Sándor Beniczky, Eglè Navickiene, Arminas Jasionis, Mariana Lunardi, Graciela Falco, Peter Wolf

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: This study aimed to analyse the effect of neuropsychological activation methods on interictal epileptiform discharges, compared to standard activation methods, for both focal and generalized epilepsies. Methods: This was a multicentre, prospective study including 429 consecutive EEG recordings of individuals with confirmed or suspected diagnosis of epilepsy. Neuropsychological activation included reading aloud in foreign and native language, praxis and a letter cancelation task (each with a duration of three minutes). After counting interictal discharges in three-minute time windows, activation and inhibition were assessed for each procedure, accounting for spontaneous fluctuations (95% CI) and compared to the baseline condition with eyes closed. Differences between generalized and focal epilepsies were explored. Results: Interictal epileptiform discharges were present in 59.4% of the recordings. Activation was seen during hyperventilation in 31%, in at least one neuropsychological activation method in 15.4%), during intermittent photic simulation in 13.1% and in the resting condition with eyes open in 9.9%. The most frequent single cognitive task eliciting activation was praxis (10.3%). Lasting activation responses were found in 18–25%. Significant inhibition was found in 88/98 patients with baseline interictal epileptiform discharges, and was not task-specific. Significance: Adding a brief neuropsychological activation protocol to the standard EEG slightly increased its sensitivity in patients with either focal or generalized epilepsy. However, in unselected epilepsy patients, this effect seems only exceptionally to result in ultimate diagnostic gain, compared to standard procedures. From a diagnostic perspective, cognitive tasks should be reserved for patients with a suspicion of cognitive reflex epilepsy/seizures and probably require longer exposure times. Further research is needed to explore potential therapeutic applications of the observed inhibition of interictal epileptiform discharges by cognitive tasks in some patients.

Original languageEnglish
JournalEpileptic Disorders
Volume23
Issue number1
Pages (from-to)123-132
ISSN1294-9361
DOIs
Publication statusPublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2021 Epileptic Disorders

Keywords

  • electroencephalography
  • epilepsy
  • external modulation
  • interictal epileptiform discharges
  • neuropsychological activation
  • reflex seizures

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