Cognitive impairment and mortality among nonagenarians: The Danish 1905-cohort survey

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Abstract

Cognitive impairment has been associated with increased mortality. Most studies, however, have only included small numbers, if at all, of the very old. In a large nationwide survey of all Danes born in 1905 and still alive in 1998, where the baseline examination was conducted, we examined the impact of cognitive impairment on mortality over a 2-year period. No cognitive impairment was defined as a score of 24-30 points on the Mini Mental State Examination, mild cognitive impairment was defined as a score of 18-23 points, and severe impairment was defined as a score of 0-17 points. Cox regression analysis was applied to adjust for a number of known and suspected factors known or suspected of being associated with cognition and mortality (e.g. sociodemographic factors, sex, smoking, alcohol consumption, depressive symptoms, and physical abilities), and yielded hazard ratios (95% confidence interval) of 1.24 (1.00-1.55) for mildly impaired and 1.73 (1.37-2.20) for severely impaired Danes compared to individuals with no impairment. Cognitive impairment predicts mortality among the very old, even after controlling for most known predictors of mortality.
Original languageEnglish
JournalDementia and Geriatric Cognitive Disorders
Volume13
Issue number3
Pages (from-to)156-163
Number of pages8
ISSN1420-8008
DOIs
Publication statusPublished - 2002

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Sex Factors
Alcohol Drinking
Cognition
Smoking
Regression Analysis
Cognitive Dysfunction
Surveys and Questionnaires
Confidence Intervals
Depression

Keywords

  • Aged
  • Aged, 80 and over
  • Cognition Disorders
  • Cohort Studies
  • Denmark
  • Female
  • Humans
  • Male
  • Mental Status Schedule
  • Proportional Hazards Models
  • Risk Factors

Cite this

@article{10342e10ba9911dc9626000ea68e967b,
title = "Cognitive impairment and mortality among nonagenarians: The Danish 1905-cohort survey",
abstract = "Cognitive impairment has been associated with increased mortality. Most studies, however, have only included small numbers, if at all, of the very old. In a large nationwide survey of all Danes born in 1905 and still alive in 1998, where the baseline examination was conducted, we examined the impact of cognitive impairment on mortality over a 2-year period. No cognitive impairment was defined as a score of 24-30 points on the Mini Mental State Examination, mild cognitive impairment was defined as a score of 18-23 points, and severe impairment was defined as a score of 0-17 points. Cox regression analysis was applied to adjust for a number of known and suspected factors known or suspected of being associated with cognition and mortality (e.g. sociodemographic factors, sex, smoking, alcohol consumption, depressive symptoms, and physical abilities), and yielded hazard ratios (95{\%} confidence interval) of 1.24 (1.00-1.55) for mildly impaired and 1.73 (1.37-2.20) for severely impaired Danes compared to individuals with no impairment. Cognitive impairment predicts mortality among the very old, even after controlling for most known predictors of mortality.",
keywords = "Aged, Aged, 80 and over, Cognition Disorders, Cohort Studies, Denmark, Female, Humans, Male, Mental Status Schedule, Proportional Hazards Models, Risk Factors",
author = "Kjeld Andersen and Hanne Nybo and David Gaist and Petersen, {Hans Chr} and Matt McGue and Bernard Jeune and Vaupel, {James W} and Kaare Christensen",
note = "Copyright 2002 S. Karger AG, Basel",
year = "2002",
doi = "10.1159/000048647",
language = "English",
volume = "13",
pages = "156--163",
journal = "Dementia and Geriatric Cognitive Disorders",
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T1 - Cognitive impairment and mortality among nonagenarians

T2 - The Danish 1905-cohort survey

AU - Andersen, Kjeld

AU - Nybo, Hanne

AU - Gaist, David

AU - Petersen, Hans Chr

AU - McGue, Matt

AU - Jeune, Bernard

AU - Vaupel, James W

AU - Christensen, Kaare

N1 - Copyright 2002 S. Karger AG, Basel

PY - 2002

Y1 - 2002

N2 - Cognitive impairment has been associated with increased mortality. Most studies, however, have only included small numbers, if at all, of the very old. In a large nationwide survey of all Danes born in 1905 and still alive in 1998, where the baseline examination was conducted, we examined the impact of cognitive impairment on mortality over a 2-year period. No cognitive impairment was defined as a score of 24-30 points on the Mini Mental State Examination, mild cognitive impairment was defined as a score of 18-23 points, and severe impairment was defined as a score of 0-17 points. Cox regression analysis was applied to adjust for a number of known and suspected factors known or suspected of being associated with cognition and mortality (e.g. sociodemographic factors, sex, smoking, alcohol consumption, depressive symptoms, and physical abilities), and yielded hazard ratios (95% confidence interval) of 1.24 (1.00-1.55) for mildly impaired and 1.73 (1.37-2.20) for severely impaired Danes compared to individuals with no impairment. Cognitive impairment predicts mortality among the very old, even after controlling for most known predictors of mortality.

AB - Cognitive impairment has been associated with increased mortality. Most studies, however, have only included small numbers, if at all, of the very old. In a large nationwide survey of all Danes born in 1905 and still alive in 1998, where the baseline examination was conducted, we examined the impact of cognitive impairment on mortality over a 2-year period. No cognitive impairment was defined as a score of 24-30 points on the Mini Mental State Examination, mild cognitive impairment was defined as a score of 18-23 points, and severe impairment was defined as a score of 0-17 points. Cox regression analysis was applied to adjust for a number of known and suspected factors known or suspected of being associated with cognition and mortality (e.g. sociodemographic factors, sex, smoking, alcohol consumption, depressive symptoms, and physical abilities), and yielded hazard ratios (95% confidence interval) of 1.24 (1.00-1.55) for mildly impaired and 1.73 (1.37-2.20) for severely impaired Danes compared to individuals with no impairment. Cognitive impairment predicts mortality among the very old, even after controlling for most known predictors of mortality.

KW - Aged

KW - Aged, 80 and over

KW - Cognition Disorders

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Mental Status Schedule

KW - Proportional Hazards Models

KW - Risk Factors

U2 - 10.1159/000048647

DO - 10.1159/000048647

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JO - Dementia and Geriatric Cognitive Disorders

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SN - 1420-8008

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ER -