Clustering on Membranes

Fluctuations and More

Ludger Johannes, Weria Pezeshkian, John H Ipsen, Julian C Shillcock*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.

Original languageEnglish
JournalTrends in Cell Biology
Volume28
Issue number5
Pages (from-to)405-415
ISSN0962-8924
DOIs
Publication statusPublished - 2018

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Cluster Analysis
Membranes
Proteins
Membrane Lipids
Endocytosis
Cell Membrane
Ligands

Cite this

Johannes, Ludger ; Pezeshkian, Weria ; Ipsen, John H ; Shillcock, Julian C. / Clustering on Membranes : Fluctuations and More. In: Trends in Cell Biology. 2018 ; Vol. 28, No. 5. pp. 405-415.
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Johannes, L, Pezeshkian, W, Ipsen, JH & Shillcock, JC 2018, 'Clustering on Membranes: Fluctuations and More', Trends in Cell Biology, vol. 28, no. 5, pp. 405-415. https://doi.org/10.1016/j.tcb.2018.01.009

Clustering on Membranes : Fluctuations and More. / Johannes, Ludger; Pezeshkian, Weria; Ipsen, John H; Shillcock, Julian C.

In: Trends in Cell Biology, Vol. 28, No. 5, 2018, p. 405-415.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Clustering on Membranes

T2 - Fluctuations and More

AU - Johannes, Ludger

AU - Pezeshkian, Weria

AU - Ipsen, John H

AU - Shillcock, Julian C

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.

AB - Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocytosis. Attractive forces that originate in perturbations of the membrane's physical properties contribute to this clustering, in addition to direct protein-protein interactions. However, these membrane-mediated forces have not all been equally considered, despite their importance. In this review, we describe how line tension, lipid depletion, and membrane curvature contribute to membrane-mediated clustering. Additional attractive forces that arise from protein-induced perturbation of a membrane's fluctuations are also described. This review aims to provide a survey of the current understanding of membrane-mediated clustering and how this supports precise biological functions.

U2 - 10.1016/j.tcb.2018.01.009

DO - 10.1016/j.tcb.2018.01.009

M3 - Review

VL - 28

SP - 405

EP - 415

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 5

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