Clonidine sedation effects in children during electroencephalography

Mohammad Barzegar, Reza Piri, Mohammad Naghavi-Behzad, Masoumeh Ghasempour*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

It is very important to have proper management in children with Seizure. Electroencephalography (EEG) as a diagnostic instrument has a key role in determining the management method of seizure in children. Because of poor cooperation of some children (especially children with attention deficit hyperactivity disorders and developmental disorders) in performing EEG, it is the best choice to sedate children before EEG. The aim of present study is to evaluate the sedation efficacy of clonidine in children before EEG. In a randomized clinical trial, 45 children age 2 to 12 with seizure, who referred to Children Hospital of Tabriz University of Medical Sciences and candidate for EEG, were studied. Sedation before EEG induced by 0.5 to 2.0 mg clonidine orally. Sedation score (0 to 5) measured by using eyes condition, response to voice, and response to touch. Successful sedation, EEG performing, and hemodynamic stability were evaluated during sedation. Of all patients, 40 patients (88.88%) were sedated successfully, and EEG was performed for all of the children. Mean onset time of clonidine effect was 35.47±13.56 minutes and mean time of that the patients’ level of consciousness back to the level before administrating of clonidine was 77.55±26.87 minutes. Hemodynamic states of all patients were stable during the study, and there were no significant changes in vital sign of patients. In conclusion, clonidine can be considered as a safe alternative medication for sedation for EEG, which is fortunately associated with no significant change in vital signs, which may complicate overall status of patients.

Original languageEnglish
JournalActa Medica Iranica
Volume55
Issue number9
Pages (from-to)568-572
ISSN0044-6025
Publication statusPublished - 1. Jan 2017
Externally publishedYes

Fingerprint

Clonidine
Electroencephalography
Vital Signs
Consciousness
Randomized Controlled Trials

Keywords

  • Clonidine
  • Electroencephalography
  • Sedation

Cite this

Barzegar, Mohammad ; Piri, Reza ; Naghavi-Behzad, Mohammad ; Ghasempour, Masoumeh. / Clonidine sedation effects in children during electroencephalography. In: Acta Medica Iranica. 2017 ; Vol. 55, No. 9. pp. 568-572.
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Clonidine sedation effects in children during electroencephalography. / Barzegar, Mohammad; Piri, Reza; Naghavi-Behzad, Mohammad; Ghasempour, Masoumeh.

In: Acta Medica Iranica, Vol. 55, No. 9, 01.01.2017, p. 568-572.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Clonidine sedation effects in children during electroencephalography

AU - Barzegar, Mohammad

AU - Piri, Reza

AU - Naghavi-Behzad, Mohammad

AU - Ghasempour, Masoumeh

PY - 2017/1/1

Y1 - 2017/1/1

N2 - It is very important to have proper management in children with Seizure. Electroencephalography (EEG) as a diagnostic instrument has a key role in determining the management method of seizure in children. Because of poor cooperation of some children (especially children with attention deficit hyperactivity disorders and developmental disorders) in performing EEG, it is the best choice to sedate children before EEG. The aim of present study is to evaluate the sedation efficacy of clonidine in children before EEG. In a randomized clinical trial, 45 children age 2 to 12 with seizure, who referred to Children Hospital of Tabriz University of Medical Sciences and candidate for EEG, were studied. Sedation before EEG induced by 0.5 to 2.0 mg clonidine orally. Sedation score (0 to 5) measured by using eyes condition, response to voice, and response to touch. Successful sedation, EEG performing, and hemodynamic stability were evaluated during sedation. Of all patients, 40 patients (88.88%) were sedated successfully, and EEG was performed for all of the children. Mean onset time of clonidine effect was 35.47±13.56 minutes and mean time of that the patients’ level of consciousness back to the level before administrating of clonidine was 77.55±26.87 minutes. Hemodynamic states of all patients were stable during the study, and there were no significant changes in vital sign of patients. In conclusion, clonidine can be considered as a safe alternative medication for sedation for EEG, which is fortunately associated with no significant change in vital signs, which may complicate overall status of patients.

AB - It is very important to have proper management in children with Seizure. Electroencephalography (EEG) as a diagnostic instrument has a key role in determining the management method of seizure in children. Because of poor cooperation of some children (especially children with attention deficit hyperactivity disorders and developmental disorders) in performing EEG, it is the best choice to sedate children before EEG. The aim of present study is to evaluate the sedation efficacy of clonidine in children before EEG. In a randomized clinical trial, 45 children age 2 to 12 with seizure, who referred to Children Hospital of Tabriz University of Medical Sciences and candidate for EEG, were studied. Sedation before EEG induced by 0.5 to 2.0 mg clonidine orally. Sedation score (0 to 5) measured by using eyes condition, response to voice, and response to touch. Successful sedation, EEG performing, and hemodynamic stability were evaluated during sedation. Of all patients, 40 patients (88.88%) were sedated successfully, and EEG was performed for all of the children. Mean onset time of clonidine effect was 35.47±13.56 minutes and mean time of that the patients’ level of consciousness back to the level before administrating of clonidine was 77.55±26.87 minutes. Hemodynamic states of all patients were stable during the study, and there were no significant changes in vital sign of patients. In conclusion, clonidine can be considered as a safe alternative medication for sedation for EEG, which is fortunately associated with no significant change in vital signs, which may complicate overall status of patients.

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JO - Acta Medica Iranica

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SN - 0044-6025

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