Choroidal thickness in relation to birth parameters in 11-to 12-year-old children: The Copenhagen child cohort 2000 eye study

X.Q. Li, A. Munkholm, A. Munkholm, L. Clemmesen, E.M. Olsen, P. Jeppesen, A.M. Skovgaard, T. Jørgensen, Michael Larsen, I.C. Munch

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PURPOSE. To examine choroidal thickness in a population-based child cohort in relation to birth parameters. METHODS. The Copenhagen Child Cohort 2000 Eye Study examined 1406 children aged 11 to 12 years using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), ocular biometry and measurement of height, weight, refraction, and self-reported pubertal development status. Birth parameters were obtained from the Danish Medical Birth Registry. RESULTS. The subfoveal choroid in low birth weight children (<2500 g, n ¼ 51, mean 324 6 76 lm) was thinner than in normal birth weight children (2500-4500 g, n ¼ 1194, mean 361 6 78 lm), the difference being 37 (CI95 60 to 15) lm, P ¼ 0.001 after adjusting for age, sex, height, Tanner stage by sex, axial length, anterior chamber depth, and spherical equivalent refractive error. The subfoveal choroid in high birth weight children (>4500 g, n ¼ 48, mean 351663 lm) was comparable with normal birth weight children, P ¼ 0.44. The subfoveal choroid was thinner in preterm children, however the difference was not significant (18 [37 to 2] lm, P ¼ 0.08). Small for gestation children had thinner subfoveal choroid (19 [37 to 1] lm, P ¼ 0.04) compared with appropriate for gestation children. Longer birth length was associated with a thicker subfoveal choroid (2 [1-4] lm/cm, P ¼ 0.005). Macular choroidal thickness at 16 extrafoveal locations was measured in a subset of children and found to have the same associations with birth weight as the subfoveal choroidal thickness. CONCLUSIONS. In 11-to 12-year-old children, thinner choroids were associated with lower birth weight, lower birth length, and being small for the gestational age.

Original languageEnglish
JournalInvestigative Ophthalmology and Visual Science
Issue number1
Pages (from-to)617-624
Publication statusPublished - 2014


  • Birth weight
  • Children choroidal thickness
  • Gestational age
  • Population-based

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