Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy

Marie Préel, Gija Rackauskaite, Mads L. Larsen, Bjarne Laursen, Jakob Lorentzen, Alfred Peter Born, Jens Langhoff-Roos, Peter Uldall, Christina E. Hoei-Hansen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aim: We aimed at describing clinical findings in children with dyskinetic as compared to bilateral spastic cerebral palsy (CP). Methods: Data were extracted from the Danish nationwide CP register. Participants were born in 1999–2007 and were 5–6 years at ascertainment. Results: The total number of CP cases was 1165 of which 92 had dyskinetic and 540 bilateral spastic CP. Prevalence of dyskinetic CP was 0.16 per 1000 live births. In participants with dyskinetic compared to bilateral spastic CP, there was more frequently an Apgar level less than five at five minutes (22.7% vs. 11.2%) and neonatal seizures (43.5% vs. 28.5%), but less respiratory deficiency, hyperbilirubinaemia and sepsis. Impairment based on gross motor function classification was more severe in dyskinetic CP (level III–V 90.0% vs. 66.0%). In dyskinetic CP, there was a high rate of reduced developmental quotient (68.1%), visual impairment (39.3%) and epilepsy (51.6%). Basal ganglia lesions were more prevalent in dyskinetic compared to bilateral spastic CP (27.7% vs. 12.8%). Conclusion: Cases of dyskinetic CP had overlapping clinical features with cases of bilateral spastic CP, but differed significantly in several perinatal risk factors. The children with dyskinetic CP had experienced more peri- or neonatal adverse events, and neurodevelopmental impairment was severe.

Original languageEnglish
JournalActa Paediatrica, International Journal of Paediatrics
Volume108
Issue number10
Pages (from-to)1850-1856
ISSN0803-5253
DOIs
Publication statusPublished - Oct 2019

Fingerprint

Cerebral Palsy
Live Birth

Keywords

  • Cerebral palsy
  • Dyskinetic
  • Paediatric
  • Prevalence
  • Spasticity

Cite this

Préel, Marie ; Rackauskaite, Gija ; Larsen, Mads L. ; Laursen, Bjarne ; Lorentzen, Jakob ; Born, Alfred Peter ; Langhoff-Roos, Jens ; Uldall, Peter ; Hoei-Hansen, Christina E. / Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy. In: Acta Paediatrica, International Journal of Paediatrics. 2019 ; Vol. 108, No. 10. pp. 1850-1856.
@article{85395e2c5f4d4865a0ad808a5b77a2e7,
title = "Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy",
abstract = "Aim: We aimed at describing clinical findings in children with dyskinetic as compared to bilateral spastic cerebral palsy (CP). Methods: Data were extracted from the Danish nationwide CP register. Participants were born in 1999–2007 and were 5–6 years at ascertainment. Results: The total number of CP cases was 1165 of which 92 had dyskinetic and 540 bilateral spastic CP. Prevalence of dyskinetic CP was 0.16 per 1000 live births. In participants with dyskinetic compared to bilateral spastic CP, there was more frequently an Apgar level less than five at five minutes (22.7{\%} vs. 11.2{\%}) and neonatal seizures (43.5{\%} vs. 28.5{\%}), but less respiratory deficiency, hyperbilirubinaemia and sepsis. Impairment based on gross motor function classification was more severe in dyskinetic CP (level III–V 90.0{\%} vs. 66.0{\%}). In dyskinetic CP, there was a high rate of reduced developmental quotient (68.1{\%}), visual impairment (39.3{\%}) and epilepsy (51.6{\%}). Basal ganglia lesions were more prevalent in dyskinetic compared to bilateral spastic CP (27.7{\%} vs. 12.8{\%}). Conclusion: Cases of dyskinetic CP had overlapping clinical features with cases of bilateral spastic CP, but differed significantly in several perinatal risk factors. The children with dyskinetic CP had experienced more peri- or neonatal adverse events, and neurodevelopmental impairment was severe.",
keywords = "Cerebral palsy, Dyskinetic, Paediatric, Prevalence, Spasticity",
author = "Marie Pr{\'e}el and Gija Rackauskaite and Larsen, {Mads L.} and Bjarne Laursen and Jakob Lorentzen and Born, {Alfred Peter} and Jens Langhoff-Roos and Peter Uldall and Hoei-Hansen, {Christina E.}",
year = "2019",
month = "10",
doi = "10.1111/apa.14806",
language = "English",
volume = "108",
pages = "1850--1856",
journal = "Acta Paediatrica",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "10",

}

Préel, M, Rackauskaite, G, Larsen, ML, Laursen, B, Lorentzen, J, Born, AP, Langhoff-Roos, J, Uldall, P & Hoei-Hansen, CE 2019, 'Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy', Acta Paediatrica, International Journal of Paediatrics, vol. 108, no. 10, pp. 1850-1856. https://doi.org/10.1111/apa.14806

Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy. / Préel, Marie; Rackauskaite, Gija; Larsen, Mads L.; Laursen, Bjarne; Lorentzen, Jakob; Born, Alfred Peter; Langhoff-Roos, Jens; Uldall, Peter; Hoei-Hansen, Christina E.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 108, No. 10, 10.2019, p. 1850-1856.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy

AU - Préel, Marie

AU - Rackauskaite, Gija

AU - Larsen, Mads L.

AU - Laursen, Bjarne

AU - Lorentzen, Jakob

AU - Born, Alfred Peter

AU - Langhoff-Roos, Jens

AU - Uldall, Peter

AU - Hoei-Hansen, Christina E.

PY - 2019/10

Y1 - 2019/10

N2 - Aim: We aimed at describing clinical findings in children with dyskinetic as compared to bilateral spastic cerebral palsy (CP). Methods: Data were extracted from the Danish nationwide CP register. Participants were born in 1999–2007 and were 5–6 years at ascertainment. Results: The total number of CP cases was 1165 of which 92 had dyskinetic and 540 bilateral spastic CP. Prevalence of dyskinetic CP was 0.16 per 1000 live births. In participants with dyskinetic compared to bilateral spastic CP, there was more frequently an Apgar level less than five at five minutes (22.7% vs. 11.2%) and neonatal seizures (43.5% vs. 28.5%), but less respiratory deficiency, hyperbilirubinaemia and sepsis. Impairment based on gross motor function classification was more severe in dyskinetic CP (level III–V 90.0% vs. 66.0%). In dyskinetic CP, there was a high rate of reduced developmental quotient (68.1%), visual impairment (39.3%) and epilepsy (51.6%). Basal ganglia lesions were more prevalent in dyskinetic compared to bilateral spastic CP (27.7% vs. 12.8%). Conclusion: Cases of dyskinetic CP had overlapping clinical features with cases of bilateral spastic CP, but differed significantly in several perinatal risk factors. The children with dyskinetic CP had experienced more peri- or neonatal adverse events, and neurodevelopmental impairment was severe.

AB - Aim: We aimed at describing clinical findings in children with dyskinetic as compared to bilateral spastic cerebral palsy (CP). Methods: Data were extracted from the Danish nationwide CP register. Participants were born in 1999–2007 and were 5–6 years at ascertainment. Results: The total number of CP cases was 1165 of which 92 had dyskinetic and 540 bilateral spastic CP. Prevalence of dyskinetic CP was 0.16 per 1000 live births. In participants with dyskinetic compared to bilateral spastic CP, there was more frequently an Apgar level less than five at five minutes (22.7% vs. 11.2%) and neonatal seizures (43.5% vs. 28.5%), but less respiratory deficiency, hyperbilirubinaemia and sepsis. Impairment based on gross motor function classification was more severe in dyskinetic CP (level III–V 90.0% vs. 66.0%). In dyskinetic CP, there was a high rate of reduced developmental quotient (68.1%), visual impairment (39.3%) and epilepsy (51.6%). Basal ganglia lesions were more prevalent in dyskinetic compared to bilateral spastic CP (27.7% vs. 12.8%). Conclusion: Cases of dyskinetic CP had overlapping clinical features with cases of bilateral spastic CP, but differed significantly in several perinatal risk factors. The children with dyskinetic CP had experienced more peri- or neonatal adverse events, and neurodevelopmental impairment was severe.

KW - Cerebral palsy

KW - Dyskinetic

KW - Paediatric

KW - Prevalence

KW - Spasticity

U2 - 10.1111/apa.14806

DO - 10.1111/apa.14806

M3 - Journal article

C2 - 30933377

AN - SCOPUS:85064674286

VL - 108

SP - 1850

EP - 1856

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 10

ER -