Children Born by Women With Rheumatoid Arthritis and Increased Susceptibility for Chronic Diseases: a nationwide cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

73 Downloads (Pure)

Abstract

Objective: Fetal exposure to maternal rheumatoid arthritis (RA) might impact the long-term risk of disease in the offspring. We examined a possible association between maternal RA and 15 selected groups of chronic diseases in the offspring. Methods: This nationwide cohort study was based on the Danish health registries and included data on all children born alive in Denmark between January 1, 1989 and December 31, 2013. The cohort comprised 2,106 children born by women with RA (exposed), and 1,378,539 children born by women without RA (unexposed). Cox proportional hazards regression models were used, taking a large range of confounders into consideration, and the hazard ratios (HRs) of child and adolescent diseases were calculated. Results: In children exposed to maternal RA in utero, the HR of thyroid diseases was 2.19 (95% confidence interval [95% CI] 1.14–4.21), epilepsy 1.61 (95% CI 1.16–2.25), and RA 2.89 (95% CI 2.06–4.05). The HRs for anxiety and personality disorders and chronic lung disease including asthma were in the range of 1.15–1.16, but these were not statistically significant associations. Conclusion: Our results suggest that in utero exposure to maternal RA is associated with an increased risk of thyroid disease and epilepsy in childhood and adolescence, and in particular an increased risk of RA, compared to children born to mothers without RA. These important findings should encourage pediatricians and general practitioners to have an increased awareness of certain chronic diseases in children exposed to RA in utero.

Original languageEnglish
JournalArthritis Care & Research
Volume70
Issue number8
Pages (from-to)1192-1197
ISSN2151-464X
DOIs
Publication statusPublished - Aug 2018

Fingerprint

Cohort Studies
Maternal Exposure
Mothers
Confidence Intervals
Denmark
Proportional Hazards Models
General Practitioners
Lung Diseases
Registries
Health

Bibliographical note

© 2017, American College of Rheumatology.

Keywords

  • Journal Article

Cite this

@article{10482e60b96948c1bcca97ac3bedd8a2,
title = "Children Born by Women With Rheumatoid Arthritis and Increased Susceptibility for Chronic Diseases: a nationwide cohort study",
abstract = "Objective: Fetal exposure to maternal rheumatoid arthritis (RA) might impact the long-term risk of disease in the offspring. We examined a possible association between maternal RA and 15 selected groups of chronic diseases in the offspring. Methods: This nationwide cohort study was based on the Danish health registries and included data on all children born alive in Denmark between January 1, 1989 and December 31, 2013. The cohort comprised 2,106 children born by women with RA (exposed), and 1,378,539 children born by women without RA (unexposed). Cox proportional hazards regression models were used, taking a large range of confounders into consideration, and the hazard ratios (HRs) of child and adolescent diseases were calculated. Results: In children exposed to maternal RA in utero, the HR of thyroid diseases was 2.19 (95{\%} confidence interval [95{\%} CI] 1.14–4.21), epilepsy 1.61 (95{\%} CI 1.16–2.25), and RA 2.89 (95{\%} CI 2.06–4.05). The HRs for anxiety and personality disorders and chronic lung disease including asthma were in the range of 1.15–1.16, but these were not statistically significant associations. Conclusion: Our results suggest that in utero exposure to maternal RA is associated with an increased risk of thyroid disease and epilepsy in childhood and adolescence, and in particular an increased risk of RA, compared to children born to mothers without RA. These important findings should encourage pediatricians and general practitioners to have an increased awareness of certain chronic diseases in children exposed to RA in utero.",
keywords = "Journal Article",
author = "J{\o}lving, {Line Riis} and Jan Nielsen and Kesmodel, {Ulrik Schi{\o}ler} and Signe Beck-Nielsen and N{\o}rg{\aa}rd, {Bente Mertz}",
note = "{\circledC} 2017, American College of Rheumatology.",
year = "2018",
month = "8",
doi = "10.1002/acr.23461",
language = "English",
volume = "70",
pages = "1192--1197",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "JohnWiley & Sons, Inc.",
number = "8",

}

Children Born by Women With Rheumatoid Arthritis and Increased Susceptibility for Chronic Diseases : a nationwide cohort study. / Jølving, Line Riis ; Nielsen, Jan; Kesmodel, Ulrik Schiøler; Beck-Nielsen, Signe; Nørgård, Bente Mertz.

In: Arthritis Care & Research, Vol. 70, No. 8, 08.2018, p. 1192-1197.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Children Born by Women With Rheumatoid Arthritis and Increased Susceptibility for Chronic Diseases

T2 - a nationwide cohort study

AU - Jølving, Line Riis

AU - Nielsen, Jan

AU - Kesmodel, Ulrik Schiøler

AU - Beck-Nielsen, Signe

AU - Nørgård, Bente Mertz

N1 - © 2017, American College of Rheumatology.

PY - 2018/8

Y1 - 2018/8

N2 - Objective: Fetal exposure to maternal rheumatoid arthritis (RA) might impact the long-term risk of disease in the offspring. We examined a possible association between maternal RA and 15 selected groups of chronic diseases in the offspring. Methods: This nationwide cohort study was based on the Danish health registries and included data on all children born alive in Denmark between January 1, 1989 and December 31, 2013. The cohort comprised 2,106 children born by women with RA (exposed), and 1,378,539 children born by women without RA (unexposed). Cox proportional hazards regression models were used, taking a large range of confounders into consideration, and the hazard ratios (HRs) of child and adolescent diseases were calculated. Results: In children exposed to maternal RA in utero, the HR of thyroid diseases was 2.19 (95% confidence interval [95% CI] 1.14–4.21), epilepsy 1.61 (95% CI 1.16–2.25), and RA 2.89 (95% CI 2.06–4.05). The HRs for anxiety and personality disorders and chronic lung disease including asthma were in the range of 1.15–1.16, but these were not statistically significant associations. Conclusion: Our results suggest that in utero exposure to maternal RA is associated with an increased risk of thyroid disease and epilepsy in childhood and adolescence, and in particular an increased risk of RA, compared to children born to mothers without RA. These important findings should encourage pediatricians and general practitioners to have an increased awareness of certain chronic diseases in children exposed to RA in utero.

AB - Objective: Fetal exposure to maternal rheumatoid arthritis (RA) might impact the long-term risk of disease in the offspring. We examined a possible association between maternal RA and 15 selected groups of chronic diseases in the offspring. Methods: This nationwide cohort study was based on the Danish health registries and included data on all children born alive in Denmark between January 1, 1989 and December 31, 2013. The cohort comprised 2,106 children born by women with RA (exposed), and 1,378,539 children born by women without RA (unexposed). Cox proportional hazards regression models were used, taking a large range of confounders into consideration, and the hazard ratios (HRs) of child and adolescent diseases were calculated. Results: In children exposed to maternal RA in utero, the HR of thyroid diseases was 2.19 (95% confidence interval [95% CI] 1.14–4.21), epilepsy 1.61 (95% CI 1.16–2.25), and RA 2.89 (95% CI 2.06–4.05). The HRs for anxiety and personality disorders and chronic lung disease including asthma were in the range of 1.15–1.16, but these were not statistically significant associations. Conclusion: Our results suggest that in utero exposure to maternal RA is associated with an increased risk of thyroid disease and epilepsy in childhood and adolescence, and in particular an increased risk of RA, compared to children born to mothers without RA. These important findings should encourage pediatricians and general practitioners to have an increased awareness of certain chronic diseases in children exposed to RA in utero.

KW - Journal Article

U2 - 10.1002/acr.23461

DO - 10.1002/acr.23461

M3 - Journal article

C2 - 29226569

VL - 70

SP - 1192

EP - 1197

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 8

ER -