Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing

Nina Ank; Thomas V Sydenham; Lene H Iversen; Ulrik S Justesen; Mikala Wang

doi:10.1016/j.ijantimicag.2015.02.024

Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing

Nina Ank, Thomas V Sydenham, Lene H Iversen, Ulrik S Justesen, Mikala Wang

KI, Clinical Microbiology

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-genome sequencing of the isolate resulted in identification of nimE, cfiA and ermF genes corresponding to metronidazole, carbapenem and clindamycin resistance.

Original language	English
Journal	International Journal of Antimicrobial Agents
Volume	46
Issue number	1
Pages (from-to)	117-120
ISSN	0924-8579
DOIs	https://doi.org/10.1016/j.ijantimicag.2015.02.024
Publication status	Published - 2015

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title = "Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing",

abstract = "Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-genome sequencing of the isolate resulted in identification of nimE, cfiA and ermF genes corresponding to metronidazole, carbapenem and clindamycin resistance.",

author = "Nina Ank and Sydenham, {Thomas V} and Iversen, {Lene H} and Justesen, {Ulrik S} and Mikala Wang",

year = "2015",

doi = "10.1016/j.ijantimicag.2015.02.024",

language = "English",

volume = "46",

pages = "117--120",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier",

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Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing. / Ank, Nina; Sydenham, Thomas V; Iversen, Lene H; Justesen, Ulrik S; Wang, Mikala.

In: International Journal of Antimicrobial Agents, Vol. 46, No. 1, 2015, p. 117-120.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Characterisation of a multidrug-resistant Bacteroides fragilis isolate recovered from blood of a patient in Denmark using whole-genome sequencing

AU - Ank, Nina

AU - Sydenham, Thomas V

AU - Iversen, Lene H

AU - Justesen, Ulrik S

AU - Wang, Mikala

PY - 2015

Y1 - 2015

N2 - Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-genome sequencing of the isolate resulted in identification of nimE, cfiA and ermF genes corresponding to metronidazole, carbapenem and clindamycin resistance.

AB - Here we describe a patient undergoing extensive abdominal surgery and hyperthermic intraperitoneal chemotherapy due to primary adenocarcinoma in the sigmoid colon with peritoneal carcinomatosis. During hospitalisation the patient suffered from bacteraemia with a multidrug-resistant Bacteroides fragilis isolate. Whole-genome sequencing of the isolate resulted in identification of nimE, cfiA and ermF genes corresponding to metronidazole, carbapenem and clindamycin resistance.

U2 - 10.1016/j.ijantimicag.2015.02.024

DO - 10.1016/j.ijantimicag.2015.02.024

M3 - Journal article

C2 - 25940770

VL - 46

SP - 117

EP - 120

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 1

ER -