Changes in physical performance and their association with health-related quality of life in a mixed nonischemic cardiac population that participates in rehabilitation

Lars Hermann Tang, Ann Dorthe Olsen Zwisler, Patrick Doherty, Neil Oldridge, Selina Kikkenborg Berg, Jan Christensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose: Exercise-based cardiac rehabilitation improves physical performance and health-related quality of life (HRQoL). However, whether improvements in physical performance are associated with changes in HRQoL has not been adequately investigated in a nonischemic cardiac population. Methods: Patients who were ablated for atrial fibrillation, who underwent heart valve surgery or who were treated for infective endocarditis, and who participated in 1 of 3 randomized controlled rehabilitation trials were eligible for the current study. Change in physical performance and HRQoL were measured before and after a 12-wk exercise intervention. Physical performance was assessed using a cardiopulmonary exercise test, a 6-min walk test, and a sit-to-stand test. Health-related quality of life was assessed using the generic 36-Item Short Form Health Survey and the disease-specific HeartQoL questionnaire. Spearman correlation coefficient (ρ) and linear regressions quantified the association between changes in physical outcome measures and changes in HRQoL. Results: A total of 344 patients were included (mean age: 60.8 ± 11.6 yr and 77% males). Associations between changes in physical outcome measures and HRQoL ranged from very weak to weak (ρ = -0.056 to 0.228). The observed associations were more dominant within physical dimensions of the HRQoL compared with mental or emotional dimensions. After adjusting for sex, age, and diagnosis, changes in physical performance explained no more than 20% of the variation in the HRQoL. Conclusion: The findings show that the positive improvement in HRQoL from exercise-based cardiac rehabilitation cannot simply be explained by an improvement in physical performance.

Original languageEnglish
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Number of pages6
ISSN1932-7501
DOIs
Publication statusE-pub ahead of print - 24. Apr 2019

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Quality of Life
Population
Exercise
Outcome Assessment (Health Care)
Heart Valves
Health Surveys
Exercise Test
Linear Models
Randomized Controlled Trials

Keywords

  • atrial fibrillation
  • cardiac rehabilitation
  • heart valve surgery
  • infective endocarditis

Cite this

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title = "Changes in physical performance and their association with health-related quality of life in a mixed nonischemic cardiac population that participates in rehabilitation",
abstract = "Purpose: Exercise-based cardiac rehabilitation improves physical performance and health-related quality of life (HRQoL). However, whether improvements in physical performance are associated with changes in HRQoL has not been adequately investigated in a nonischemic cardiac population. Methods: Patients who were ablated for atrial fibrillation, who underwent heart valve surgery or who were treated for infective endocarditis, and who participated in 1 of 3 randomized controlled rehabilitation trials were eligible for the current study. Change in physical performance and HRQoL were measured before and after a 12-wk exercise intervention. Physical performance was assessed using a cardiopulmonary exercise test, a 6-min walk test, and a sit-to-stand test. Health-related quality of life was assessed using the generic 36-Item Short Form Health Survey and the disease-specific HeartQoL questionnaire. Spearman correlation coefficient (ρ) and linear regressions quantified the association between changes in physical outcome measures and changes in HRQoL. Results: A total of 344 patients were included (mean age: 60.8 ± 11.6 yr and 77{\%} males). Associations between changes in physical outcome measures and HRQoL ranged from very weak to weak (ρ = -0.056 to 0.228). The observed associations were more dominant within physical dimensions of the HRQoL compared with mental or emotional dimensions. After adjusting for sex, age, and diagnosis, changes in physical performance explained no more than 20{\%} of the variation in the HRQoL. Conclusion: The findings show that the positive improvement in HRQoL from exercise-based cardiac rehabilitation cannot simply be explained by an improvement in physical performance.",
keywords = "atrial fibrillation, cardiac rehabilitation, heart valve surgery, infective endocarditis",
author = "Tang, {Lars Hermann} and Zwisler, {Ann Dorthe Olsen} and Patrick Doherty and Neil Oldridge and Berg, {Selina Kikkenborg} and Jan Christensen",
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Changes in physical performance and their association with health-related quality of life in a mixed nonischemic cardiac population that participates in rehabilitation. / Tang, Lars Hermann; Zwisler, Ann Dorthe Olsen; Doherty, Patrick; Oldridge, Neil; Berg, Selina Kikkenborg; Christensen, Jan.

In: Journal of Cardiopulmonary Rehabilitation and Prevention, 24.04.2019.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Changes in physical performance and their association with health-related quality of life in a mixed nonischemic cardiac population that participates in rehabilitation

AU - Tang, Lars Hermann

AU - Zwisler, Ann Dorthe Olsen

AU - Doherty, Patrick

AU - Oldridge, Neil

AU - Berg, Selina Kikkenborg

AU - Christensen, Jan

PY - 2019/4/24

Y1 - 2019/4/24

N2 - Purpose: Exercise-based cardiac rehabilitation improves physical performance and health-related quality of life (HRQoL). However, whether improvements in physical performance are associated with changes in HRQoL has not been adequately investigated in a nonischemic cardiac population. Methods: Patients who were ablated for atrial fibrillation, who underwent heart valve surgery or who were treated for infective endocarditis, and who participated in 1 of 3 randomized controlled rehabilitation trials were eligible for the current study. Change in physical performance and HRQoL were measured before and after a 12-wk exercise intervention. Physical performance was assessed using a cardiopulmonary exercise test, a 6-min walk test, and a sit-to-stand test. Health-related quality of life was assessed using the generic 36-Item Short Form Health Survey and the disease-specific HeartQoL questionnaire. Spearman correlation coefficient (ρ) and linear regressions quantified the association between changes in physical outcome measures and changes in HRQoL. Results: A total of 344 patients were included (mean age: 60.8 ± 11.6 yr and 77% males). Associations between changes in physical outcome measures and HRQoL ranged from very weak to weak (ρ = -0.056 to 0.228). The observed associations were more dominant within physical dimensions of the HRQoL compared with mental or emotional dimensions. After adjusting for sex, age, and diagnosis, changes in physical performance explained no more than 20% of the variation in the HRQoL. Conclusion: The findings show that the positive improvement in HRQoL from exercise-based cardiac rehabilitation cannot simply be explained by an improvement in physical performance.

AB - Purpose: Exercise-based cardiac rehabilitation improves physical performance and health-related quality of life (HRQoL). However, whether improvements in physical performance are associated with changes in HRQoL has not been adequately investigated in a nonischemic cardiac population. Methods: Patients who were ablated for atrial fibrillation, who underwent heart valve surgery or who were treated for infective endocarditis, and who participated in 1 of 3 randomized controlled rehabilitation trials were eligible for the current study. Change in physical performance and HRQoL were measured before and after a 12-wk exercise intervention. Physical performance was assessed using a cardiopulmonary exercise test, a 6-min walk test, and a sit-to-stand test. Health-related quality of life was assessed using the generic 36-Item Short Form Health Survey and the disease-specific HeartQoL questionnaire. Spearman correlation coefficient (ρ) and linear regressions quantified the association between changes in physical outcome measures and changes in HRQoL. Results: A total of 344 patients were included (mean age: 60.8 ± 11.6 yr and 77% males). Associations between changes in physical outcome measures and HRQoL ranged from very weak to weak (ρ = -0.056 to 0.228). The observed associations were more dominant within physical dimensions of the HRQoL compared with mental or emotional dimensions. After adjusting for sex, age, and diagnosis, changes in physical performance explained no more than 20% of the variation in the HRQoL. Conclusion: The findings show that the positive improvement in HRQoL from exercise-based cardiac rehabilitation cannot simply be explained by an improvement in physical performance.

KW - atrial fibrillation

KW - cardiac rehabilitation

KW - heart valve surgery

KW - infective endocarditis

U2 - 10.1097/HCR.0000000000000416

DO - 10.1097/HCR.0000000000000416

M3 - Journal article

C2 - 31033637

JO - Journal of Cardiopulmonary Rehabilitation and Prevention

JF - Journal of Cardiopulmonary Rehabilitation and Prevention

SN - 1932-7501

ER -