Changes in cognitive functions and cerebral grey matter and their associations with inflammatory markers, endocrine markers, and APOE genotypes in testicular cancer patients undergoing treatment

Ali Amidi, Mads Agerbæk, Lisa M. Wu, Anders D. Pedersen, Mimi Mehlsen, Cecilie R. Clausen, Ditte Demontis, Anders D. Børglum, Anja Harbøll, Robert Zachariae

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Evidence suggests that testicular cancer (TC) and its treatment are associated with cognitive impairment. However, the underlying neural substrate and biological mechanisms are poorly understood. This study aimed to investigate changes in cognition and brain grey matter (GM) morphology in TC patients undergoing treatment, and to explore associations with immune markers, endocrine markers, and genotype. Sixty-five patients with stage I-III TC underwent assessment after surgery but prior to further treatment and again 6 months after. Twenty-two patients received chemotherapy (+CT), while 43 did not (−CT). Assessments included neuropsychological testing, whole-brain magnetic resonance imaging, and blood samples. Twenty-five healthy controls (HCs) underwent neuropsychological testing with a matching time interval. A regression-based approach was used to determine cognitive changes and longitudinal voxel-based morphometry (VBM) was performed to investigate changes in GM density in the TC groups. Compared with the HCs, both TC groups showed higher rates of cognitive decline (p 
Original languageEnglish
JournalBrain Imaging and Behavior
Issue number3
Pages (from-to)769-783
Publication statusPublished - 1. Jun 2017
Externally publishedYes


  • APOE
  • Cancer
  • Cognition
  • Cortisol
  • Cytokine
  • Germ cell tumor
  • MRI
  • Neurocognitive function
  • Neuropsychological function
  • Testicular cancer
  • Voxel-based morphometry

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